Synthesis and antiviral evaluation of some carbonucleoside analogues

被引：5

作者：

Alho, MAM

Errea, MI

Sguerra, VL

D'Accorso, NB ^{[1
]}

Talarico, LB

García, CC

Damonte, EB

机构：

[1] Consejo Nacl Invest Cient & Tecn, CIHIDECAR, Fac Ciencias Exactas & Nat, Dept Quim Organ, RA-1033 Buenos Aires, DF, Argentina

[2] Fac Ciencias Exactas & Nat Buenos Aires, Dept Quim Biol, Buenos Aires, DF, Argentina

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2005年 / 42卷 / 05期

关键词：

D O I：

10.1002/jhet.5570420536

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2-O-Isopropylidene-alpha-L-threofuranosyl heterocyclic derivatives were synthesized from 1,2-O-isopropylidene-alpha-D-xilopentadialdo-1,4-furanose and tested for antiviral activity against herpes simplex virus type 1, dengue virus type 2 and Junin virus. For comparative propose, the antiviral activity of some of their pyranosyl analogues were also tested. The furanosyl derivatives showed to be moderate inhibitors of Junin virus and, in general, proved to be more effective than the pyranosyl analogues.

引用

页码：979 / 983

页数：5

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