Physicochemical and structural properties of lidocaine-based ionic liquids with anti-inflammatory anions

被引：33

作者：

Panic, Jovana ^{[1
]}

Tot, Aleksandar ^{[1
]}

Jankovic, Nenad ^{[2
]}

Drid, Patrik ^{[3
]}

Gadzuric, Slobodan ^{[1
]}

Vranes, Milan ^{[1
]}

机构：

[1] Univ Novi Sad, Dept Chem Biochem & Environm Protect, Fac Sci, Trg Dositeja Obradovica 3, Novi Sad 21000, Serbia

[2] Univ Kragujevac, Fac Sci, Dept Chem, Radoja Damanovica 12, Kragujevac 34000, Serbia

[3] Univ Novi Sad, Fac Sport & Phys Educ, Lovcenska 16, Novi Sad 21000, Serbia

来源：

RSC ADVANCES | 2020年 / 10卷 / 24期

关键词：

VISCOSITY; IBUPROFEN; FORMS;

D O I：

10.1039/c9ra08815f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The purpose of this paper was to examine the density, viscosity and electrical conductivity at different temperatures, as well as the thermal stability and structural properties of previously reported ionic liquids based on active pharmaceutical ingredients. Lidocaine-based ionic liquids, with ibuprofen and salicylate as counterion, were prepared first. Their structures were confirmed by infrared, mass and H-1 and C-13 nuclear magnetic resonance spectroscopy. The Newtonian behaviour of lidocaine ibuprofenate was confirmed from viscosity measurement results, while it was impossible to determine for lidocaine salicylate. The interactions and structures of the studied ionic liquids were analyzed based on the measured density values, viscosity, electrical conductivity, and calculated values of thermal expansion coefficients and activation energy of viscous flow. From a theoretical aspect, DFT and MD calculations were performed. The obtained descriptors and radial distribution, as well as structural functions, were used to understand the structural organization of the synthesized ionic liquids.

引用

页码：14089 / 14098

页数：10

共 21 条

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