Filament capping and nucleation in actin-based motility

被引：5
|
作者：
Faber, M. [1 ]
Enculescu, M. [2 ]
Falcke, M. [1 ]
机构：
[1] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany
[2] Tech Univ Berlin, Inst Theoret Phys, D-10623 Berlin, Germany
来源：
EUROPEAN PHYSICAL JOURNAL-SPECIAL TOPICS | 2010年 / 191卷 / 01期
关键词：
LISTERIA-MONOCYTOGENES; PROTRUSION PHENOTYPES; DRIVEN; POLYMERIZATION; KERATOCYTES; PROPULSION; MECHANISM; PROTEINS; DYNAMICS;
D O I：
10.1140/epjst/e2010-01347-3
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
Propulsion by actin polymerization is versatilely used in cell motility. Here, we investigate a model of the semi-flexible region of an actin gel close to a propelled object describing the force generation, the dynamics of the propagation velocity, filament attachment to and detachment from the obstacle surface and dynamics of the number of filaments, which result from filament nucleation and capping. The model equations are derived as moment equations of the length distributions. We find a variety of dynamic regimes. The filament number may respond very sensitively to small changes of the attachment rate.
引用
收藏
页码：147 / 158
页数：12
相关论文
共 50 条
  • [41] Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility
    Haglund, Cat M.
    Choe, Julie E.
    Skau, Colleen T.
    Kovar, David R.
    Welch, Matthew D.
    NATURE CELL BIOLOGY, 2010, 12 (11) : 1057 - U40
  • [42] Gelsolin as a calcium-regulated actin filament-capping protein
    Gremm, D
    Wegner, A
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (14): : 4339 - 4345
  • [43] Dendritic Actin Filament Nucleation Causes Traveling Waves and Patches
    Carlsson, Anders E.
    PHYSICAL REVIEW LETTERS, 2010, 104 (22)
  • [44] Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation
    Namgoong, Suk
    Boczkowska, Malgorzata
    Glista, Michael J.
    Winkelman, Jonathan D.
    Rebowski, Grzegorz
    Kovar, David R.
    Dominguez, Roberto
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (09) : 1060 - U124
  • [45] Reconstitution of actin-based cellular processes: Why encapsulation changes the rules
    Kandiyoth, Fabina Binth
    Michelot, Alphee
    EUROPEAN JOURNAL OF CELL BIOLOGY, 2023, 102 (04)
  • [46] Actin based motility unveiled: How chemical energy is converted into motion
    Bonanno, C.
    Serpelloni, M.
    Arricca, M.
    McMeeking, R. M.
    Salvadori, A.
    JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS, 2023, 175
  • [47] Kinetic overshoot in actin network assembly induced jointly by branching and capping proteins
    Kang, Hyeran
    Carlsson, Anders E.
    Tang, Jay X.
    PHYSICAL REVIEW E, 2009, 80 (04):
  • [48] Actin hydrophobic loop 262-274 and filament nucleation and elongation
    Shvetsov, Alexander
    Galkin, Vitold E.
    Orlova, Albina
    Phillips, Martin
    Bergeron, Sarah E.
    Rubenstein, Peter A.
    Egelman, Edward H.
    Reisler, Emil
    JOURNAL OF MOLECULAR BIOLOGY, 2008, 375 (03) : 793 - 801
  • [49] Actin filament nucleation and elongation factors - structure-function relationships
    Dominguez, Roberto
    CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2009, 44 (06) : 351 - 366
  • [50] Transition to superdiffusive behavior in intracellular actin-based transport mediated by molecular motors
    Bruno, L.
    Levi, V.
    Brunstein, M.
    Desposito, M. A.
    PHYSICAL REVIEW E, 2009, 80 (01):
12345