DSPE-PEG: A Distinctive Component in Drug Delivery System

被引：119

作者：

Che, Jing ^{[1
,2
]}

Okeke, Chukwunweike I. ^{[1
]}

Hu, Zhong-Bo ^{[2
]}

Xu, Jing ^{[1
]}

机构：

[1] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China

来源：

CURRENT PHARMACEUTICAL DESIGN | 2015年 / 21卷 / 12期

关键词：

DSPE-PEG; blood circulation time; biostability; liposomes; micelles; drug delivery; POLYMER HYBRID NANOPARTICLES; IN-VIVO; POLY(ETHYLENE GLYCOL); THERMOSENSITIVE LIPOSOMES; PEGYLATED LIPOSOMES; TARGETING DELIVERY; STEALTH LIPOSOMES; CELLULAR UPTAKE; SIRNA DELIVERY; RELEASE;

D O I：

10.2174/1381612821666150115144003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-Poly(ethylene glycol) (DSPE-PEG) is a widely used phospholipids-polymer conjugate in drug delivery applications. It is a biocompatible, biodegradable and amphiphilic material which can also be functionalized with various biomolecules for specific functions. With the emerging interest in use of nanocarriers for therapeutic drug delivery and imaging DSPE-PEG has become a very useful material for the formulation of these nanocarriers for achieving prolonged blood circulation time, improved stability and enhanced encapsulation efficiency. This review will focus on the relationships between the structure of DSPE-PEG and its noticeable effects on these nanocarriers' properties, and the recent progress on the development of DSPE-PEG and its derivatives in delivery systems.

引用

页码：1598 / 1605

页数：8

共 82 条

[11] Reversible photoswitching conjugated polymer nanoparticles for cell and ex vivo tumor imaging [J].

Feng, Guangxue ;

Ding, Dan ;

Li, Kai ;

Liu, Jie ;

Liu, Bin .

NANOSCALE, 2014, 6 (08) :4141-4147

[12] Two cholesterol derivative-based PEGylated liposomes as drug delivery system, study on pharmacokinetics and drug delivery to retina [J].

Geng, Shengyong ;

Yang, Bin ;

Wang, Guowu ;

Qin, Geng ;

Wada, Satoshi ;

Wang, Jin-Ye .

NANOTECHNOLOGY, 2014, 25 (27)

[13] Novel serum-tolerant lipoplexes target the folate receptor efficiently [J].

Gorle, Sridevi ;

Ariatti, Mario ;

Singh, Moganavelli .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2014, 59 :83-93

[14] Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review [J].

Hadinoto, Kunn ;

Sundaresan, Ajitha ;

Cheow, Wean Sin .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2013, 85 (03) :427-443

[15] The Polyethyleneglycol Dilemma: Advantage and Disadvantage of PEGylation of Liposomes for Systemic Genes and Nucleic Acids Delivery to Tumors [J].

Hatakeyama, Hiroto ;

Akita, Hidetaka ;

Harashima, Hideyoshi .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2013, 36 (06) :892-899

[16] Synthesis and characterization of novel poly(ethylene glycol)-lipid conjugates suitable for use in drug delivery [J].

Heyes, James ;

Hall, Kim ;

Tailor, Vicky ;

Lenz, Richard ;

MacLachlan, Ian .

JOURNAL OF CONTROLLED RELEASE, 2006, 112 (02) :280-290

[17]

Hong RL, 1999, CLIN CANCER RES, V5, P3645

[18] Proteins and cholesterol lipid vesicles are mediators of drug release from thermosensitive liposomes [J].

Hossann, Martin ;

Syunyaeva, Zulfiya ;

Schmidt, Rebecca ;

Zengerle, Anja ;

Eibl, Hansjoerg ;

Issels, Rolf D. ;

Lindner, Lars H. .

JOURNAL OF CONTROLLED RELEASE, 2012, 162 (02) :400-406

[19]

Jain A, 2013, J NANOPART RES, V15

[20] Stimulated Release of Cholesterol from Liposomal Membranes by a PEGylated Phospholipid [J].

Janout, Vaclav ;

Daly, Trevor A. ;

Cline, Lauren L. ;

Kulp, Leah J. ;

Regen, Steven L. .

BIOCONJUGATE CHEMISTRY, 2012, 23 (03) :336-339

← 1 2 3 4 5 6 7 8 9 →