DSPE-PEG: A Distinctive Component in Drug Delivery System

被引：119
作者：
Che, Jing [1 ,2 ]
Okeke, Chukwunweike I. [1 ]
Hu, Zhong-Bo [2 ]
Xu, Jing [1 ]
机构：
[1] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
来源：
CURRENT PHARMACEUTICAL DESIGN | 2015年 / 21卷 / 12期
关键词：
DSPE-PEG; blood circulation time; biostability; liposomes; micelles; drug delivery; POLYMER HYBRID NANOPARTICLES; IN-VIVO; POLY(ETHYLENE GLYCOL); THERMOSENSITIVE LIPOSOMES; PEGYLATED LIPOSOMES; TARGETING DELIVERY; STEALTH LIPOSOMES; CELLULAR UPTAKE; SIRNA DELIVERY; RELEASE;
D O I：
10.2174/1381612821666150115144003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-Poly(ethylene glycol) (DSPE-PEG) is a widely used phospholipids-polymer conjugate in drug delivery applications. It is a biocompatible, biodegradable and amphiphilic material which can also be functionalized with various biomolecules for specific functions. With the emerging interest in use of nanocarriers for therapeutic drug delivery and imaging DSPE-PEG has become a very useful material for the formulation of these nanocarriers for achieving prolonged blood circulation time, improved stability and enhanced encapsulation efficiency. This review will focus on the relationships between the structure of DSPE-PEG and its noticeable effects on these nanocarriers' properties, and the recent progress on the development of DSPE-PEG and its derivatives in delivery systems.
引用
收藏
页码：1598 / 1605
页数：8
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