Comprehensive assessment for novel prostate cancer markers in the prostate-specific antigen era: Focusing on Asians and Asian countries

被引:8
|
作者
Okihara, Koji [1 ]
Ochiai, Atsushi [1 ]
Kamoi, Kazumi [1 ]
Fujizuka, Yuji [2 ]
Miki, Tsuneharu [1 ]
Ito, Kazuto [2 ]
机构
[1] Kyoto Prefectural Univ Med, Dept Urol, Kyoto 6028566, Japan
[2] Gunma Univ, Grad Sch Med, Dept Urol, Maebashi, Gunma 371, Japan
关键词
Asia; proPSA; prostate cancer; PCA3; TMPRSS2:ERG; HEALTH INDEX PHI; MOLECULAR URINE TEST; RADICAL PROSTATECTOMY; GENE FUSIONS; PCA3; MULTICENTER EVALUATION; ACTIVE SURVEILLANCE; ISOFORM P2PSA; TOTAL PSA; JAPANESE;
D O I
10.1111/iju.12701
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
We reviewed the current evidence for three novel prostate tumor markers (PCA3, TMPRSS2:ERG and proPSA) that have been recently reported predominantly in Western countries. We focus our attention on Asian men in both clinical and basic research studies. There have been no reports on the clinical usefulness of these three markers for Asians living in Western countries. In Asian countries, evidence for the clinical usefulness of PCA3 and proPSA-related indices including Prostate Health Index is being accumulated, mainly in Japan. The process for how a novel marker is approved in the clinical setting is also discussed.
引用
收藏
页码:334 / 341
页数:8
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