AQP1 expression in the proximal tubule of diabetic rat kidney

被引：10

作者：

Seyahian, Erika A. ^{[1
,2
]}

Cacciagiu, Leornardo ^{[3
]}

Damiano, Alicia E. ^{[1
,4
]}

Zotta, Elsa ^{[1
,2
]}

机构：

[1] Univ Buenos Aires, CONICET, Fac Med, Inst Fisiol & Biofis Bernardo Houssay IFIBIO, Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Farm & Bioquim, Dept Ciencias Biol, Catedra Fisiopatol, Buenos Aires, DF, Argentina

[3] Hosp Cesar Milstein, Lab Cent, Secc Quim Clin, Buenos Aires, DF, Argentina

[4] Univ Buenos Aires, Fac Farm & Bioquim, Dept Ciencias Biol, Catedra Biol Celular & Mol, Buenos Aires, DF, Argentina

来源：

HELIYON | 2020年 / 6卷 / 01期

关键词：

Biological sciences; Membrane; Pathophysiology; Renal system; Physiology; Pathology; AQP1; Diabetes mellitus; Kidney; Proximal tubule; Renal water reabsorption; Polyuria; AQUAPORIN-1; HYPERTONICITY; REABSORPTION; POLYURIA;

D O I：

10.1016/j.heliyon.2020.e03192

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Polyuria is a hallmark symptom and the first clinical manifestation of diabetes mellitus (DM). The glucose that remains in renal tubules was proposed to produce an osmotic effect resulting in polyuria. Although water is reabsorbed in proximal tubules through an aquaporin-1 (AQP1) dependent mechanism, AQP1 role in the genesis of polyuria is unknown. AQP1 expression was studied in a rat model of Type-1 DM at 15-days and 5-months of evolution. A different AQP1 expression pattern was found in both experimental groups, with no changes in AQP1 localization, suggesting that changes in AQP1 may be involved in the development of polyuria.

引用

页数：5

共 11 条

[1] Proximal Tubule Function and Response to Acidosis [J].

Curthoys, Norman P. ;

Moe, Orson W. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2014, 9 (09) :1627-1638

[2] PGE2 receptor EP3 inhibits water reabsorption and contributes to polyuria and kidney injury in a streptozotocin-induced mouse model of diabetes [J].

Hassouneh, Ramzi ;

Nasrallah, Rania ;

Zimpelmann, Joe ;

Gutsol, Alex ;

Eckert, David ;

Ghossein, Jamie ;

Burns, Kevin D. ;

Hebert, Richard L. .

DIABETOLOGIA, 2016, 59 (06) :1318-1328

[3] Renal aquaporins and water balance disorders [J].

Kortenoeven, Marleen L. A. ;

Fenton, Robert A. .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2014, 1840 (05) :1533-1549

[4] The Expression of Aquaporin-1 in the Medulla of the Kidney Is Dependent on the Transcription Factor Associated with Hypertonicity, TonEBP [J].

Lanaspa, Miguel A. ;

Andres-Hernando, Ana ;

Li, Nanxing ;

Rivard, Christopher J. ;

Cicerchi, Christina ;

Roncal-Jimenez, Carlos ;

Schrier, Robert W. ;

Berl, Tomas .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (41) :31694-31703

[5] Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice [J].

Leung, JC ;

Chan, LY ;

Tsang, AW ;

Tang, SC ;

Lai, KN .

NEPHROLOGY, 2005, 10 (01) :63-72

[6] Glucose handling by the kidney [J].

Mather, Amanda ;

Pollock, Carol .

KIDNEY INTERNATIONAL, 2011, 79 :S1-S6

[7] Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice [J].

Schnermann, J ;

Chou, CL ;

Ma, TH ;

Traynor, T ;

Knepper, MA ;

Verkman, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9660-9664

[8] Hypertonicity-induced aquaporin-1 (AQP1) expression is mediated by the activation of MAPK pathways and hypertonicity-responsive element in the AQP1 gene [J].

Umenishi, F ;

Schrier, RW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (18) :15765-15770

[9] Roles of aquaporins in kidney revealed by transgenic mice [J].

Verkman, A. S. .

SEMINARS IN NEPHROLOGY, 2006, 26 (03) :200-208

[10] Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rat [J].

Vestri, S ;

Okamoto, MM ;

de Freitas, HS ;

dos Santos, RA ;

Nunes, MT ;

Morimatsu, M ;

Heimann, JC ;

Machado, UF .

JOURNAL OF MEMBRANE BIOLOGY, 2001, 182 (02) :105-112

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