Stereocontrolled synthesis of tetrasubstituted olefins

The four different carbon-linked groups' tetrasubstituted olefins are involved in materials research because useful, structural and electronic properties that may arise from the presence of the double bond. The stereoselective synthesis of tetrasubsitutted olefins has become a challenge in organic synthesis. There are many methods have been developed and the majority of the explored routes have used alkynyl carbometallation strategies. Other methods used are classical double bond-forming methods, the Wittig and Horner-Wadsworth-Emmons reaction was also used for the formation of tetrasubstituted double bonds, however, this method encounter serious problems of generality and stereoselectivity. The McMurry coupling that have been successful in producing highly congested products, however, sterochemistry can only be controlled in cyclic cases. Today, there are strategies such as olefin metathesis, radical sequences and ynolate chemistry are starting to emerge as viable techniques for the formation of tetrasubstituted olefins and offering potential in this area.