Metabolic flexibility and cell hierarchy in metastatic cancer

被引:52
作者
Berridge, Michael V. [1 ]
Herst, Patries M. [1 ]
Tan, An S. [1 ]
机构
[1] Malaghan Inst Med Res, Wellington 6242, New Zealand
关键词
Cancer; Metastasis; Self renewal; Metabolism; Aerobic glycolysis; Mitochondrial respiration; STIMULATES AEROBIC GLYCOLYSIS; SURFACE OXYGEN-CONSUMPTION; MITOCHONDRIAL-DNA; HUMAN BRAIN; GLUCOSE-METABOLISM; ENERGY-METABOLISM; TUMOR-CELLS; STEM-CELLS; IDENTIFICATION; LEUKEMIA;
D O I
10.1016/j.mito.2010.08.002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cancer is characterized by disturbed homeostasis of self renewing cell populations and their ability to seed and grow in multiple microenvironments This overarching cellular property of metastatic cancer emerges from the contentious cancer stem cell hypothesis that underpins the more generic hallmarks of cancer (Hanahan and Weinberg 2000) and its subsequent add ons An additional characteristic metabolic flexibility is related to concepts developed by Warburg and to subsequent work by mid 20th century biochemists who elucidated the bioenergetic workings of mitochondria Metabolic flexibility may circumvent limitations Inherent in the increasingly popular but erroneous view that aerobic glycolysis is a universal property of cancer cells Cancer research in the second half of the 20th century was largely the domain of geneticists and molecular biologists using reductionist approaches Integrated approaches that address cancer cell hierarchy and complexity and how cancer cells adapt their metabolism according to their changing environment are now beginning to emerge and these approaches promise to address the poor mortality statistics of metastatic cancer (C) 2010 Elsevier B V and Mitochondria Research Society All tights reserved
引用
收藏
页码:584 / 588
页数:5
相关论文
共 50 条
[31]   Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation [J].
Ricciardelli, Carmela ;
Lokman, Noor A. ;
Cheruvu, Sowmya ;
Tan, Izza A. ;
Ween, Miranda P. ;
Pyragius, Carmen E. ;
Ruszkiewicz, Andrew ;
Hoffmann, Peter ;
Oehler, Martin K. .
CLINICAL & EXPERIMENTAL METASTASIS, 2015, 32 (05) :441-455
[32]   Research Progress on Bioenergy Metabolic Mechanism of Cancer [J].
Luo Xiang-Jian ;
Cao Ya .
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2011, 38 (07) :585-592
[33]   New aspects of the Warburg effect in cancer cell biology [J].
Bensinger, Steven J. ;
Christofk, Heather R. .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2012, 23 (04) :352-361
[34]   Cancer Stem Cell Metabolism and Potential Therapeutic Targets [J].
Snyder, Vusala ;
Reed-Newman, Tamika C. ;
Arnold, Levi ;
Thomas, Sufi Mary ;
Anant, Shrikant .
FRONTIERS IN ONCOLOGY, 2018, 8
[35]   Metabolic plasticity and hematopoietic stem cell biology [J].
Hsu, Peter ;
Qu, Cheng-Kui .
CURRENT OPINION IN HEMATOLOGY, 2013, 20 (04) :289-294
[36]   Circadian rhythms in cardiac metabolic flexibility [J].
Young, Martin E. ;
Latimer, Mary N. .
CHRONOBIOLOGY INTERNATIONAL, 2023, 40 (01) :13-26
[37]   The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide [J].
Oleson, Bryndon J. ;
Broniowska, Katarzyna A. ;
Yeo, Chay Teng ;
Flancher, Michael ;
Naatz, Aaron ;
Hogg, Neil ;
Tarakanova, Vera L. ;
Corbett, John A. .
MOLECULAR AND CELLULAR BIOLOGY, 2019, 39 (18)
[38]   Metabolic reprogramming of mitochondrial respiration in metastatic cancer [J].
P. M. Herst ;
C. Grasso ;
Michael V. Berridge .
Cancer and Metastasis Reviews, 2018, 37 :643-653
[39]   Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy [J].
Patel, Shyam A. ;
Ramkissoon, Shakti H. ;
Bryan, Margarette ;
Pliner, Lillian F. ;
Dontu, Gabriela ;
Patel, Prem S. ;
Amiri, Sohrab ;
Pine, Sharon R. ;
Rameshwar, Pranela .
SCIENTIFIC REPORTS, 2012, 2
[40]   Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade [J].
Lue, Hui-wen ;
Podolak, Jennifer ;
Kolahi, Kevin ;
Cheng, Larry ;
Rao, Soumya ;
Garg, Devin ;
Xue, Chang-Hui ;
Rantala, Juha K. ;
Tyner, Jeffrey W. ;
Thornburg, Kent L. ;
Martinez-Acevedo, Ann ;
Liu, Jen-Jane ;
Amling, Christopher L. ;
Truillet, Charles ;
Louie, Sharon M. ;
Anderson, Kimberly E. ;
Evans, Michael J. ;
O'Donnell, Valerie B. ;
Nomura, Daniel K. ;
Drake, Justin M. ;
Ritz, Anna ;
Thomas, George V. .
GENES & DEVELOPMENT, 2017, 31 (20) :2067-2084