Procalcitonin as a Biomarker in Respiratory Tract Infection

被引：110

作者：

Gilbert, David N. ^{[1
,2
]}

机构：

[1] Providence Portland Med Ctr, Earle A Chiles Res Inst, Portland, OR 97213 USA

[2] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2011年 / 52卷

关键词：

COMMUNITY-ACQUIRED PNEUMONIA; CALCITONIN-I GENE; ANTIBIOTIC-TREATMENT; SERUM PROCALCITONIN; INFLAMMATION; EXPRESSION; PATHOGENS; DIAGNOSIS; BACTERIAL; GUIDANCE;

D O I：

10.1093/cid/cir050

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serum procalcitonin (PCT) levels rapidly increase in patients with invasive bacterial disease. PCT levels increase faster than do C-reactive protein levels. Furthermore, a rapid decrease in the PCT level is supporting evidence that the source of the bacterial infection is responding to clinical management. In patients with community-acquired bacterial pneumonia, sequential PCT levels are useful as a guide to shorter courses of antimicrobial therapy. With use of emerging multiplex real-time polymerase chain reaction platforms for the detection of viral and bacterial respiratory pathogens, it should be possible to critically assess whether an elevated serum PCT level is a valid biomarker of invasive bacterial infection.

引用

页码：S346 / S350

页数：5

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