Water movements in the brain: role of aquaporins

被引：248

作者：

Tait, Matthew J. ^{[1
]}

Saadoun, Samira ^{[1
]}

Bell, B. Anthony ^{[1
]}

Papadopoulos, Marios C. ^{[1
]}

机构：

[1] St Georges Univ London, Acad Neurosurg Unit, London SW17 0RE, England

来源：

TRENDS IN NEUROSCIENCES | 2008年 / 31卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.tins.2007.11.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

About 80% of the brain is water. This review discusses the importance of the three brain water-channel proteins (AQP1, AQP4, AQP9) in brain physiology. AQP1 is expressed in the choroid plexus and participates in forming cerebrospinal fluid. AQP4, found in astrocyte foot processes, glia limitans and ependyma, facilitates water movement into and out of the brain, accelerates astrocyte migration and alters neuronal activity. Recently, AQP4 autoantibodies were discovered in patients with neuromyelitis optica, a demyelinating disease, and are now being used to diagnose this condition. AQP9 is present in some glia and neurons, but its function is unclear. Finally, we discuss how the discovery of AQP activators and inhibitors will be the next major step in this field.

引用

页码：37 / 43

页数：7

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