Concise Review: Prostate Cancer Stem Cells: Current Understanding

被引：96

作者：

Skvortsov, Sergej ^{[1
,2
]}

Skvortsova, Ira-Ida ^{[1
,2
]}

Tang, Dean G. ^{[3
,4
]}

Dubrovska, Anna ^{[5
,6
,7
,8
,9
,10
]}

机构：

[1] Innsbruck Med Univ, Dept Therapeut Radiol & Oncol, Lab Expt & Translat Res Radiat Oncol EXTROLab, Innsbruck, Austria

[2] Tyrolean Canc Res Inst, Innsbruck, Austria

[3] Roswell Pk Canc Inst, Dept Pharmacol & Therapeut, Buffalo, NY 14263 USA

[4] Tongji Univ, Sch Med, Canc Stem Cell Inst, East Hosp,Res Ctr Translat Med, Shanghai, Peoples R China

[5] Tech Univ Dresden, OncoRay Natl Ctr Radiat Res Oncol, Fac Med, Dresden, Germany

[6] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dresden, Germany

[7] Helmholtz Zentrum Dresden Rossendorf, Dresden, Germany

[8] Helmholtz Zentrum Dresden Rossendorf, Inst Radiooncol OncoRay, Dresden, Germany

[9] German Canc Consortium DKTK, German Canc Res Ctr DKFZ, Partner Site Dresden, Heidelberg, Germany

[10] German Canc Res Ctr, Heidelberg, Germany

来源：

STEM CELLS | 2018年 / 36卷 / 10期

基金：

奥地利科学基金会; 美国国家卫生研究院;

关键词：

Prostate; Cancer; Cancer stem cells; Heterogeneity; Metabolism; CIRCULATING TUMOR-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; ANDROGEN RECEPTOR EXPRESSION; BONE METASTASIS; BREAST-CANCER; WNT/BETA-CATENIN; PROTEIN-KINASE; BASAL-CELLS; C-MYC; ALDEHYDE DEHYDROGENASE;

D O I：

10.1002/stem.2859

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Prostate cancer (PCa) is heterogeneous, harboring phenotypically diverse cancer cell types. PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition and evolution of the cancer genome and by epigenetic mechanisms that result in subclonal cellular differentiation. The process of tumor cell differentiation is initiated from a population of prostate cancer stem cells (PCSCs) that possess many phenotypic and functional properties of normal stem cells. Since the initial reports on PCSCs in 2005, there has been much effort to elucidate their biological properties, including unique metabolic characteristics. In this Review, we discuss the current methods for PCSC enrichment and analysis, the hallmarks of PCSC metabolism, and the role of PCSCs in tumor progression.

引用

收藏

页码：1457 / 1474

页数：18

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