Peptide fibrillization

被引：550
作者：
Hamley, Ian W. [1 ]
机构：
[1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 43期
关键词：
amyloids; biomaterials; peptides; self-assembly; soft matter;
D O I：
10.1002/anie.200700861
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The fibrillization of peptides is relevant to many diseases based on the deposition of amyloids. The formation of fibrils is being intensively studied, especially in terms of nanotechnology applications, where fibrillar peptide hydrogels are used for cell scaffolds, as supports for functional and responsive biomaterials, biosensors, and nanowires. This Review is concerned with fundamental aspects of the self-assembly of peptides into fibrils, and discusses both natural amyloid-forming peptides and synthetic materials, including peptide fragments, copolymers, and amphiphiles.
引用
收藏
页码：8128 / 8147
页数：20
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