PERITONEAL PROTEIN CLEARANCE RATHER THAN FASTER TRANSPORT STATUS DETERMINES OUTCOMES IN PERITONEAL DIALYSIS PATIENTS

被引：41

作者：

Rajakaruna, Gayathri ^{[1
]}

Caplin, Ben ^{[1
]}

Davenport, Andrew ^{[1
]}

机构：

[1] UCL, Sch Med, Royal Free Hosp, UCL Ctr Nephrol, London NW3 2PF, England

来源：

PERITONEAL DIALYSIS INTERNATIONAL | 2015年 / 35卷 / 02期

关键词：

Bioimpedance; survival; extracellular fluid; peritoneal protein loss; fast transporter; EQUILIBRATION TEST; NATRIURETIC PEPTIDE; MEMBRANE-TRANSPORT; BIOIMPEDANCE; SURVIVAL; VOLUMES;

D O I：

10.3747/pdi.2013.00217

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Faster peritoneal transport has been associated with an increased risk of therapy failure and patient mortality. However, faster transport can the result of many factors. Peritoneal protein clearance (PPC) has been proposed to distinguish faster peritoneal transport attributable to inflammatory conditions, as protein clearance reflects large-pore flow, which increases during inflammation. We followed a cohort of 300 peritoneal dialysis patients, and after adjustments for age and comorbidity, higher PPC was associated with increased risk of death (hazard ratio: 1.81; 95% confidence interval: 1.11 to 2.95), even after patients underwent transplantation or transferred to hemodialysis.

引用

页码：216 / 221

页数：6

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