Novel selenium-containing photosensitizers for near-infrared fluorescence imaging-guided photodynamic therapy

被引：7

作者：

Jiang, Meiyu ^{[1
,2
,3
]}

Wu, Jiasheng ^{[1
,2
]}

Liu, Weimin ^{[1
,2
,3
]}

Ren, Haohui ^{[1
,2
]}

Wang, Shuai ^{[1
,2
,3
]}

Wang, Pengfei ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Tech Inst Phys & Chem, CityU CAS Joint Lab Funct Mat & Devices, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2022年 / 233卷

关键词：

Selenium; Photosensitizer; Photodynamic therapy; NIR fluorescence imaging; NANOPARTICLES;

D O I：

10.1016/j.jphotobiol.2022.112488

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Benzopyran nitrile dyes cannot be used as qualified photosensitizers due to the low quantum yield of triplet state. The benzopyran derivatives containing selenium instead of oxygen atom based on the heavy atom effect are expected to become potential agents for photodynamic therapy. In this paper, a series of selenium-containing photosensitizers (PSx) were prepared according to this strategy. PSx can effectively produce both singlet oxygen and superoxide anions upon laser irradiation. PSx exhibited the emission wavelength at 500-800 nm and near-infrared (NIR) fluorescence imaging in HeLa cells. Excellent biocompatibility and phototoxicity further indicated that PSx could be used as efficient photosensitizers for NIR fluorescence imaging and photodynamic therapy.

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页数：8

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