Racemic immunosuppressive seco-aporphine derivatives from Thalictrurn wangii

被引：6

作者：

Jin, Qiong ^{[1
,2
]}

Wei, Xin ^{[1
,3
]}

Qin, Xu-Jie ^{[1
]}

Gao, Fei ^{[2
]}

Zhu, Pei-Feng ^{[1
]}

Yuan, Hai-Lian ^{[1
,2
]}

Njateng, Guy Sedar Singor ^{[1
]}

Dai, Zhi ^{[1
,2
]}

Liu, Ya-Ping ^{[1
]}

Luo, Xiao-Dong ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ & Yunnan Prov, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China

[3] Guizhou Univ Tradit Chinese Med, Guiyang 550025, Peoples R China

来源：

FITOTERAPIA | 2020年 / 140卷

关键词：

seco-aporphine derivatives; Immunosuppressive bioactivity; Thalictrum wangii; ALKALOIDS; METHOTREXATE; EXPRESSION;

D O I：

10.1016/j.fitote.2019.104445

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thallactones A (1) and B (2), enantiomeric aporphine alkaloids with rare cleaved rings A and B, as well as thaliglucine N-oxide (3) and their biosynthetically related precursor, northalphenine (4), were isolated from the whole plant of Thalictrum wangii Their structures with absolute configurations were elucidated by spectral techniques and electronic circular dichroism (ECD). Moreover, compounds 1, 3, and northalphenine inhibited concanavalin A (Con A)-stimulated proliferation of mice splenocyte significantly in a dose-dependent manner.

引用

页数：6

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