Epidemiological, clinical and pathological aspects of follicular lymphoma in dogs

被引:0
作者
Mazaro, Renata D. [1 ]
Rizkallah, Isis P. J. [3 ]
Luz, Flavia S. [1 ]
Lorensetti, Douglas M. [2 ]
Cogliati, Bruno [3 ]
Fighera, Rafael A. [4 ]
机构
[1] Univ Fed Santa Maria, CCR, Programa Posgrad Med Vet, Area Concentracao Patol & Patol Clin Vet, Av Roraima 1000, BR-97105900 Santa Maria, RS, Brazil
[2] Univ Fed Santa Maria, CCR, Curse Med Vet, PIBIC,CNPq, Santa Maria, RS, Brazil
[3] Univ Sao Paulo, FMVZ, Lab Patol Morfol & Mol Lapmol, Ave Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP, Brazil
[4] Univ Fed Santa Maria, CCS, Dept Patol, Av Roraima 1000, BR-97105900 Santa Maria, RS, Brazil
来源
PESQUISA VETERINARIA BRASILEIRA | 2018年 / 39卷 / 09期
关键词
Epidemiology; clinics; pathology; lymphoma; dogs; follicular lymphoma; indolent lymphoma; multicentric lymphoma; diseases of dogs; INSTITUTE WORKING FORMULATION; NON-HODGKINS-LYMPHOMAS; MALIGNANT-LYMPHOMA; CLASSIFICATION; CANINE; SUBTYPE; MORPHOLOGY; PATTERNS; CRITERIA;
D O I
10.1590/1678-5150-PVB-5286
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Follicular lymphomas are a rare form of lymphoproliferative disorder described in veterinary medicine. Together with the probable non-existence of Hodgkin's lymphomas in dogs, this is the biggest difference about lymphoma between humans and dogs. The aim of this article is to describe the epidemiological, clinical and anatomopathological findings observed in five dogs with follicular lymphoma. Of the five dogs with follicular lymphoma, two were male (40%) and three were female (60%). The age of affected dogs ranged from 11 to 13 years. Four of the five (80%) dogs were purebred and one (20%) had no defined breed. All dogs presented generalized lymphadenomegaly and splenomegaly, which included cases as multicentric lymphoma. At necropsy, the lymph nodes and the spleen demonstrated a nodular pattern at the cut surface, characterized by tens to hundreds of white nodules of variable size, multifocal or coalescing. On the natural surface of the spleen, often (4/5, 80%), there were myriads of white, multifocal or coalescing dots of varying sizes. In histopathology, the tumors were confirmed as follicular lymphomas. All cases were Grade Ill, two (40%) included as Illa and three (60%) as IIIb. In one case (1/5, 20%), follicular lymphoma was considered as a IIIb variant of small centroblasts similar to the neoplastic lymphocytes seen in Burkitt's lymphoma. Lymphomas were validated as having origin in B cells through immunohistochemistry, using anti-CD20 antibody. The cases of follicular lymphomas described behaved aggressively and led the patients to death.
引用
收藏
页码:1772 / 1780
页数:9
相关论文
共 29 条
[1]   Non-Hodgkin lymphoma subtype distribution, geodemographic patterns, and survival in the US: A longitudinal analysis of the National Cancer Data Base from 1998 to 2011 [J].
Al-Hamadani, Mohammed ;
Habermann, Thomas M. ;
Cerhan, James R. ;
Macon, William R. ;
Maurer, Matthew J. ;
Go, Ronald S. .
AMERICAN JOURNAL OF HEMATOLOGY, 2015, 90 (09) :790-795
[2]   Epidemiology of the non-Hodgkin's lymphomas: Distributions of the major subtypes differ by geographic locations [J].
Anderson, JR ;
Armitage, JO ;
Weisenburger, DD .
ANNALS OF ONCOLOGY, 1998, 9 (07) :717-720
[3]   Distribution of malignant lymphoma in Japan: Analysis of 2260 cases, 2001-2006 [J].
Aoki, Ryosuke ;
Karube, Kennosuke ;
Sugita, Yasuo ;
Nomura, Yuko ;
Shimizu, Kay ;
Kimura, Yoshizo ;
Hashikawa, Keiko ;
Suefuji, Nobuko ;
Kikuchi, Masahiro ;
Ohshima, Koichi .
PATHOLOGY INTERNATIONAL, 2008, 58 (03) :174-182
[4]   Indolent Lymphomas That Present With Clinically Aggressive Features: A Subset of Low-Grade Lymphomas With a Behavior Inconsistent With the Histologic Diagnosis [J].
Cabanillas, Fernando ;
Rivera, Noridza ;
Pardo, Wandaly I. .
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2016, 16 (10) :550-557
[5]   The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications [J].
Campo, Elias ;
Swerdlow, Steven H. ;
Harris, Nancy L. ;
Pileri, Stefano ;
Stein, Harald ;
Jaffe, Elaine S. .
BLOOD, 2011, 117 (19) :5019-5032
[6]   Two Hundred Three Cases of Equine Lymphoma Classified According to the World Health Organization (WHO) Classification Criteria [J].
Durham, A. C. ;
Pillitteri, C. A. ;
San Myint, M. ;
Valli, V. E. .
VETERINARY PATHOLOGY, 2013, 50 (01) :86-93
[7]  
Federico M, 2000, BLOOD, V95, P783
[8]   Clinical, histopathological and immunohistochemical characterization of canine indolent lymphoma [J].
Flood-Knapik, K. E. ;
Durham, A. C. ;
Gregor, T. P. ;
Sanchez, M. D. ;
Durney, M. E. ;
Sorenmo, K. U. .
VETERINARY AND COMPARATIVE ONCOLOGY, 2013, 11 (04) :272-286
[10]   Retrospective study of 82 cases of canine lymphoma in Austria based on the working formulation and immunophenotyping [J].
Guija de Arespacochaga, A. ;
Schwendenwein, I. ;
Weissenboeck, H. .
JOURNAL OF COMPARATIVE PATHOLOGY, 2007, 136 (2-3) :186-192