Nicotine exposure during pregnancy is a factor which influences serotonin transporter density in the rat brain

被引：44
作者：
Muneoka, K
Ogawa, T
Kamei, K
Mimura, Y
Kato, H
Takigawa, M
机构：
[1] Kagoshima Univ, Fac Med, Dept Neuropsychiat, Kagoshima 8908520, Japan
[2] Teikoku Hormone Mfg Co Ltd, Safety Res Dept, Kawasaki, Kanagawa 2138522, Japan
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2001年 / 411卷 / 03期
关键词：
nicotine; 5-HT; (5-hydroxytryptamine; serotonin); transporter; paroxetine; pregnancy; smoking;
D O I：
10.1016/S0014-2999(00)00925-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We examined the effects of nicotine exposure during pregnancy on serotonin transporter (SERT) expression in the brain. Nicotine (6 mg/kg/day) was administered to pregnant rats via subcutaneous injections or infusion pumps. irrespective of the route of administration, nicotine increased SERT density in the forebrain on postnatal day 22, but not in the other brain regions. Our results suggest that nicotine use by pregnant women might be an environmental factor influencing SERT expression in their children. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：279 / 282
页数：4
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