Differential expression of micro RNA-29 family in non-diabetic adults of diabetic and non-diabetic parents

被引：1

作者：

Abbas, Uzair ^{[1
]}

Imdad, Bushra ^{[1
]}

Mughal, Sikander Adil ^{[1
]}

Baloch, Israr Ahmed ^{[2
]}

Khan, Afshan Mehboob ^{[1
]}

Kamran, Durr-e-Sameen ^{[3
]}

机构：

[1] Dow Univ Hlth Sci, Dept Physiol, Karachi, Pakistan

[2] Mayo Clin, Dept Educ & Res, Jacksonville, FL USA

[3] Dow Univ Hlth Sci, Dept Pathol, Karachi, Pakistan

来源：

BMC RESEARCH NOTES | 2021年 / 14卷 / 01期

关键词：

Diabetes mellitus; Early diagnosis; Biomarker; Micro RNA; CIRCULATING MICRORNAS; COMPLICATIONS; MIRNAS; RISK;

D O I：

10.1186/s13104-021-05703-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective: MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders inclusive of diabetes mellitus and its complications. While micro RNA profile changes years before the occurrence of disease. This cross-sectional study was conducted in non-diabetic adults of diabetic and non-diabetic parents to explore the early changes in expression of micro RNA-29 family as it can be served as early biomarker of type 2 diabetes in non-diabetic adults. This study was conducted from January 2019 to January 2021. Micro RNA was extracted from plasma of 50 participants and expression was compared through qPCR. While data was analyzed through SPSS version 21.0. Results: 29a and 29b had lower expression in participants with family history of DM compared to those having no family history of DM (P < 0.0001). While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).

引用

页数：6

共 22 条

[11] MicroRNA-29a Promotion of Nephrin Acetylation Ameliorates Hyperglycemia-Induced Podocyte Dysfunction [J].