Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer

被引：116
作者：
Hutchinson, Marsha-Kay N. D. [1 ]
Mierzwa, Michelle [2 ]
D'Silva, Nisha J. [1 ,3 ]
机构：
[1] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, 1011 North Univ Ave, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Radiat Oncol, Ann Arbor, MI USA
[3] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI USA
来源：
ONCOGENE | 2020年 / 39卷 / 18期
关键词：
GROWTH-FACTOR RECEPTOR; STRAND BREAK REPAIR; DEPENDENT PROTEIN-KINASE; DNA-DAMAGE-RESPONSE; IONIZING-RADIATION; LIGASE-IV; HUMAN-PAPILLOMAVIRUS; SALVAGE SURGERY; XRCC4; PROTEIN; P53;
D O I：
10.1038/s41388-020-1250-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Radiation is a significant treatment for patients with head and neck cancer. Despite advances to improve treatment, many tumors acquire radiation resistance resulting in poor survival. Radiation kills cancer cells by inducing DNA double-strand breaks. Therefore, radiation resistance is enhanced by efficient repair of damaged DNA. Head and neck cancers overexpress EGFR and have a high frequency of p53 mutations, both of which enhance DNA repair. This review discusses the clinical criteria for radiation resistance in patients with head and neck cancer and summarizes how cancer cells evade radiation-mediated apoptosis by p53- and epidermal growth factor receptor (EGFR)-mediated DNA repair. In addition, we explore the role of cancer stem cells in promoting radiation resistance, and how the abscopal effect provides rationale for combination strategies with immunotherapy.
引用
收藏
页码：3638 / 3649
页数：12
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