Metastatic Prostate Cancer With Restored Hormone-Response After Radioligand Therapy With 177Lu-PSMA-617

被引：12

作者：

Schlenkhoff, Carl Diedrich ^{[1
]}

Knuepfer, Eberhard ^{[2
]}

Essler, Markus ^{[1
]}

Ahmadzadehfar, Hojjat ^{[1
]}

机构：

[1] Univ Hosp Bonn, Dept Nucl Med, Sigmund Freud Str 25, D-53127 Bonn, Germany

[2] Private Off Urol, Bonn, Germany

来源：

CLINICAL NUCLEAR MEDICINE | 2016年 / 41卷 / 07期

关键词：

Lu-177-PSMA therapy; castrate-resistant prostate cancer; Ga-68-PSMA-PET; hormone therapy; PET/CT; DIAGNOSIS;

D O I：

10.1097/RLU.0000000000001200

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

An 80-year-old patient with castrate-resistant prostate cancer presented to our department for PSMA imaging because of a rising prostatespecific antigen (PSA) level. The tumorwas diagnosed in 2004. GnRh analog was the only treatment the patient received. Two cycles of Lu-177-PSMA-617 were performed with a 2-month interval in between. Ten months after finishing with 2 cycles of Lu-PSMA therapy, we noticed a continuous falling PSA level and a decreasing tumor spread in the PET/CT imaging just under the hormone therapy.

引用

页码：572 / 573

页数：2

共 8 条

[1] [68Ga]Gallium-labelled PSMA ligand as superior PET tracer for the diagnosis of prostate cancer: comparison with 18F-FECH [J].

Afshar-Oromieh, A. ;

Haberkorn, U. ;

Eder, M. ;

Eisenhut, M. ;

Zechmann, C. M. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2012, 39 (06) :1085-1086

[2] The Theranostic PSMA Ligand PSMA-617 in the Diagnosis of Prostate Cancer by PET/CT: Biodistribution in Humans, Radiation Dosimetry, and First Evaluation of Tumor Lesions [J].

Afshar-Oromieh, Ali ;

Hetzheim, Henrik ;

Kratochwil, Clemens ;

Benesova, Martina ;

Eder, Matthias ;

Neels, Oliver C. ;

Eisenhut, Michael ;

Kuebler, Wolfgang ;

Holland-Letz, Tim ;

Giesel, Frederik L. ;

Mier, Walter ;

Kopka, Klaus ;

Haberkorn, Uwe .

JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (11) :1697-1705

[3] The diagnostic value of PET/CT imaging with the 68Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer [J].

Afshar-Oromieh, Ali ;

Avtzi, Eleni ;

Giesel, Frederik L. ;

Holland-Letz, Tim ;

Linhart, Heinz G. ;

Eder, Matthias ;

Eisenhut, Michael ;

Boxler, Silvan ;

Hadaschik, Boris A. ;

Kratochwil, Clemens ;

Weichert, Wilko ;

Kopka, Klaus ;

Debus, Juergen ;

Haberkorn, Uwe .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 (02) :197-209

[4] Early side effects and first results of radioligand therapy with 177Lu-DKFZ-617 PSMA of castrate-resistant metastatic prostate cancer: a two-centre study [J].

Ahmadzadehfar, Hojjat ;

Rahbar, Kambiz ;

Kuerpig, Stefan ;

Boegemann, Martin ;

Claesener, Michael ;

Eppard, Elisabeth ;

Gaertner, Florian ;

Rogenhofer, Sebastian ;

Schaefers, Michael ;

Essler, Markus .

EJNMMI RESEARCH, 2015, 5 :1-8

[5] [177Lu]Lutetium-labelled PSMA ligand-induced remission in a patient with metastatic prostate cancer [J].

Kratochwil, Clemens ;

Giesel, Frederik L. ;

Eder, Matthias ;

Afshar-Oromieh, Ali ;

Benesova, Martina ;

Mier, Walter ;

Kopka, Klaus ;

Haberkorn, Uwe .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 (06) :987-988

[6] Prospective Comparison of 18F-Fluoromethylcholine Versus 68Ga-PSMA PET/CT in Prostate Cancer Patients Who Have Rising PSA After Curative Treatment and Are Being Considered for Targeted Therapy [J].

Morigi, Joshua J. ;

Stricker, Phillip D. ;

van Leeuwen, Pim J. ;

Tang, Reuben ;

Ho, Bao ;

Quoc Nguyen ;

Hruby, George ;

Fogarty, Gerald ;

Jagavkar, Raj ;

Kneebone, Andrew ;

Hickey, Adam ;

Fanti, Stefano ;

Tarlinton, Lisa ;

Emmett, Louise .

JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (08) :1185-1190

[7] Phase II Study of Lutetium-177-Labeled Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody J591 for Metastatic Castration-Resistant Prostate Cancer [J].

Tagawa, Scott T. ;

Milowsky, Matthew I. ;

Morris, Michael ;

Vallabhajosula, Shankar ;

Christos, Paul ;

Akhtar, Naveed H. ;

Osborne, Joseph ;

Goldsmith, Stanley J. ;

Larson, Steve ;

Taskar, Neeta Pandit ;

Scher, Howard I. ;

Bander, Neil H. ;

Nanus, David M. .

CLINICAL CANCER RESEARCH, 2013, 19 (18) :5182-5191

[8] 68Ga- and 177Lu-Labeled PSMA I&T: Optimization of a PSMA-Targeted Theranostic Concept and First Proof-of-Concept Human Studies [J].

Weineisen, Martina ;

Schottelius, Margret ;

Simecek, Jakub ;

Baum, Richard P. ;

Yildiz, Akin ;

Beykan, Seval ;

Kulkarni, Harshad R. ;

Lassmann, Michael ;

Klette, Ingo ;

Eiber, Matthias ;

Schwaiger, Markus ;

Wester, Hans-Juergen .

JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (08) :1169-1176

← 1 →