Synthesis and bioassay of aminosulfonyl-1,3,4-oxadiazoles and their interconversion to 1,3,4-thiadiazoles

被引：30

作者：

Padmavathi, V. ^{[1
]}

Reddy, S. Nagi ^{[1
]}

Reddy, G. Dinneswara ^{[1
]}

Padmaja, A. ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 09期

关键词：

1,3,4-oxadiazole; 1,3,4-thiadiazole; Phosphorus oxychloride; Thiourea; Antimicrobial activity; Antioxidant activity; LINKED BIS HETEROCYCLES; ANTIINFLAMMATORY ACTIVITY; 1,3,4-OXADIAZOLES; AGENTS; 5-LIPOXYGENASE; CYCLOOXYGENASE; DERIVATIVES; DESIGN;

D O I：

10.1016/j.ejmech.2010.06.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new class of oxadiazoles is prepared by treating aminosulfonylacetic acids with different carboxylic acid hydrazides. Interconversion of oxadiazoles to thiadiazoles is carried out with thiourea. The compounds are screened for antimicrobial and antioxidant activities. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：4246 / 4251

页数：6

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