The impact of replacement therapy on dental health in haemophilia

被引：1

作者：

Kozma, Andrei ^{[1
,10
,11
]}

Clevet, Oana ^{[2
]}

Traila, Adina ^{[2
]}

Ursu, Emilia ^{[3
]}

Jinca, Cristian ^{[4
]}

Oancea, Roxana ^{[4
]}

Boeriu, Estera ^{[4
]}

Boia, Eugeniu ^{[4
]}

Ritli, Ladislau ^{[5
]}

Serban, Margit ^{[3
]}

Lackner, Agnes Katherine ^{[6
]}

Lazarescu, Horia ^{[7
]}

Popovici, Calin ^{[1
]}

Diac, Iulia ^{[8
]}

Stanescu, Ana Maria Alexandra ^{[9
]}

Enachescu, C. I. ^{[12
]}

Arghirescu, Smaranda ^{[4
]}

机构：

[1] Alessandrescu Rusescu Natl Inst Mother & Child Hl, Res Dept Social Paediat & Obstet, Bucharest, Romania

[2] C Serban Rehabil Med Ctr Children & Adolescents, European Haemophilia Treatment Ctr, Buzias, Romania

[3] Louis Turcanu Children Emergency Hosp, European Haemophilia Treatment Ctr, Timisoara, Romania

[4] Victor Babes Univ Med & Pharm, Timisoara, Romania

[5] Univ Med & Pharm, Oradea, Romania

[6] Med Univ Vienna, Univ Dent Clin, Dept Paediat Dent, Vienna, Austria

[7] Natl Inst Recovery Phys Med & Balneoclimathol, Bucharest, Romania

[8] Carol Davila Univ Med & Pharm, Fac Med, Dept Legal Med & Bioeth, Bucharest, Romania

[9] Carol Davila Univ Med & Pharm, Fac Med, Dept Family Med, Bucharest, Romania

[10] Romanian Acad Med Sci, Bucharest, Romania

[11] Acad Romanian Scientists, Bucharest, Romania

[12] Elias Hosp, Bucharest, Romania

来源：

ROMANIAN JOURNAL OF LEGAL MEDICINE | 2019年 / 27卷 / 02期

关键词：

pharmacologic replacement therapy; coagulation factor VIII and IX concentrates; haemophilia; dental health; DMFT index; PLI index; CHILDREN; HISTORY;

D O I：

10.4323/rjlm.2019.200

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Aim. To evaluate the dental health status and its relationship with the replacement therapy in persons with haemophilia (PwH). Material and methods. In this descriptive non-interventional cross-sectional study we included a number of 47 patients, divided in 2 distinct age groups: 12 patients under- and 35 above 18 years of age. Demographic information, laboratory findings and dental health status were recorded in a standard form. Dental health was evaluated by means of the decay -missing- filling teeth (DMFT) index and plaque index (PLI); these parameters were correlated with the quality of replacement therapy and compared to a matched control group. Results and discussions. The image offered by our descriptive cross-sectional study revealed a dental status in hemophilic children comparable with that of the children from the matched control group. On the contrary, adult PwH have a dismal DMFT and PLI indexes; they are in significant correlations with the quantity and frequency of replaced coagulation factors. Conclusions. The findings highlight the need of comprehensive oral examinations including preventive dental treatment and follow-up care in the PwH connected to an adequate replacement therapy.

引用

页码：200 / 204

页数：5

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