Synthesis, DNA-binding and photocleavage of "light switch" complexes [Ru(bpy)2(pyip)]2+ and [Ru(phen)2(pyip)]2+

被引：32

作者：

Liu, Xue-Wen ^{[1
,2
]}

Shen, You-Ming ^{[1
]}

Lu, Ji-Lin ^{[1
]}

Chen, Yuan-Dao ^{[1
,2
]}

Li, Lin ^{[1
]}

Zhang, Da-Shun ^{[1
]}

机构：

[1] Hunan Univ Arts & Sci, Coll Chem & Chem Engn, Changde 415000, Peoples R China

[2] Xiangtan Univ, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2010年 / 77卷 / 02期

关键词：

Ru(II) complex; Polypyridyl ligand; Light switch; DNA-binding; Photocleavage; MODIFIED DIPYRIDOPHENAZINE LIGANDS; RUTHENIUM(II) COMPLEXES; CLEAVAGE; PROBE; BASE; ACID;

D O I：

10.1016/j.saa.2010.06.030

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Two novel Ru(II) complexes [Ru(bpy)(2)(pyip)](2+) 1 and [Ru(phen)(2)(pyip)](2+) 2 (bpy = 2,2'-bipyridine; phen = 1,10-phenanthroline; pyip= 2-(pyridine-2-yl)imidazo-[4,5f][1,10]-phenanthroline), have been synthesized and characterized by elemental analysis. ES-MS, H-1 NMR, UV-Vis. The DNA-binding behaviors of both complexes were studied by spectroscopic methods and viscosity measurements. The results indicate that the two complexes can bind to CT-DNA in an intercalative mode, and also show that these two Ru(II) complexes can promote the photocleavage of pBR322 DNA. In addition, In the presence of Co2+, the emission of DNA-[Ru(L)(2)pyip](2+) can be quenched, which exhibited the DNA "light switch" properties. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：522 / 527

页数：6

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