Antimalarial dihydroisocoumarins produced by Geotrichum sp., an endophytic fungus of Crassocephalum crepidioides

被引：97

作者：

Kongsaeree, P

Prabpai, S

Sriubolmas, N

Vongvein, C

Wiyakrutta, S

机构：

[1] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Sci, Ctr Prot Struct & Funct, Bangkok 10400, Thailand

[3] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Microbiol, Bangkok 10300, Thailand

[4] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 05期

关键词：

D O I：

10.1021/np0205598

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three novel dihydroisocoumarin derivatives (1-3) with antimalarial, antituberculous, and antifungal activities have been isolated by bioassay-guided fractionation from an endophytic fungus, Geotrichum sp., collected from Crassocephalum crepidioides. Structures were established as 7-butyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (1), 7-but-15-enyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (2), and 7-butyl-6,8-dihydroxy-3(R)-pentylisochroman-1-one (3) using spectroscopic data.

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页码：709 / 711

页数：3

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