Copper(I)-Catalyzed 3-Position Methylation of Coumarins by Using Di-tert-butyl Peroxide as the Methylation Reagents

被引：20

作者：

Zhuang, Huan ^{[1
]}

Zeng, Runsheng ^{[1
]}

Zou, Jianping ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2016年 / 34卷 / 04期

基金：

中国国家自然科学基金;

关键词：

CuCl; di-tert-butyl peroxide; methylation; coumarin; PALLADIUM-CATALYZED METHYLATION; C-H METHYLATION; BOND FUNCTIONALIZATION; COUPLING REACTION; CAFFEINE; INHIBITORS; DISCOVERY; OXINDOLES; ALKENES; SYSTEM;

D O I：

10.1002/cjoc.201500836

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The copper-catalyzed methylation of coumarin by using di-tert-butyl peroxide (DTBP) has been described. The reaction provides direct access to a wide range of 3-methylcoumarins in moderate to good yields. In this procedure, it is noteworthy that DTBP was employed not only as the oxidant, but also as the methyl source.

引用

页码：368 / 372

页数：5

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