Developing tools for defining and establishing pathways of toxicity

被引:11
作者
Andersen, Melvin E. [1 ]
McMullen, Patrick D. [1 ]
Krewski, Daniel [2 ,3 ]
机构
[1] Hamner Inst Hlth Sci, Res Triangle Pk, NC 27709 USA
[2] Univ Ottawa, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada
[3] Risk Sci Int, Ottawa, ON, Canada
关键词
GENE-EXPRESSION; VISION; 21ST-CENTURY; NETWORKS; MODULES;
D O I
10.1007/s00204-015-1512-y
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
引用
收藏
页码:809 / 812
页数:4
相关论文
共 24 条
[1]   Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment [J].
Adeleye, Yeyejide ;
Andersen, Melvin ;
Clewell, Rebecca ;
Davies, Michael ;
Dent, Matthew ;
Edwards, Sue ;
Fowler, Paul ;
Malcomber, Sophie ;
Nicol, Beate ;
Scott, Andrew ;
Scott, Sharon ;
Sun, Bin ;
Westmoreland, Carl ;
White, Andrew ;
Zhang, Qiang ;
Carmichael, Paul L. .
TOXICOLOGY, 2015, 332 :102-111
[2]   Can Case Study Approaches Speed Implementation of the NRC Report: "Toxicity Testing in the 21st Century: A Vision and a Strategy?" [J].
Andersen, Melvin E. ;
Clewell, Harvey J., III ;
Carmichael, Paul L. ;
Boekelheide, Kim .
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2011, 28 (03) :175-182
[3]   The Vision of Toxicity Testing in the 21st Century: Moving from Discussion to Action [J].
Andersen, Melvin E. ;
Krewski, Daniel .
TOXICOLOGICAL SCIENCES, 2010, 117 (01) :17-24
[4]   Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential [J].
Attene-Ramos, Matias S. ;
Huang, Ruili ;
Michael, Sam ;
Witt, Kristine L. ;
Richard, Ann ;
Tice, Raymond R. ;
Simeonov, Anton ;
Austin, Christopher P. ;
Xia, Menghang .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2015, 123 (01) :49-56
[5]   Computational discovery of gene modules and regulatory networks [J].
Bar-Joseph, Z ;
Gerber, GK ;
Lee, TI ;
Rinaldi, NJ ;
Yoo, JY ;
Robert, F ;
Gordon, DB ;
Fraenkel, E ;
Jaakkola, TS ;
Young, RA ;
Gifford, DK .
NATURE BIOTECHNOLOGY, 2003, 21 (11) :1337-1342
[6]  
Boekelheide Kim, 2010, ALTEX, V27, P243
[7]   Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver [J].
Dere, Edward ;
Lo, Raymond ;
Celius, Trine ;
Matthews, Jason ;
Zacharewski, Timothy R. .
BMC GENOMICS, 2011, 12
[8]   Inferring cellular networks using probabilistic graphical models [J].
Friedman, N .
SCIENCE, 2004, 303 (5659) :799-805
[9]   Food for Thought ... on Mapping the Human Toxome [J].
Hartung, Thomas ;
McBride, Mary .
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2011, 28 (02) :83-93
[10]   Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity [J].
Judson, Richard S. ;
Martin, Matthew T. ;
Reif, David M. ;
Houck, Keith A. ;
Knudsen, Thomas B. ;
Rotroff, Daniel M. ;
Xia, Menghang ;
Sakamuru, Srilatha ;
Huang, Ruili ;
Shinn, Paul ;
Austin, Christopher P. ;
Kavlock, Robert J. ;
Dix, David J. .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2010, 44 (15) :5979-5985