Platinum Iodide-Catalyzed Formal Three-Component Cascade Cycloaddition Reactions between γ-Aminoalkynes and Electron-Deficient Alkynes

被引：2

作者：

Li, Xinhong ^{[1
,2
]}

Jiang, Chunhui ^{[3
]}

Wang, Xiao ^{[1
,2
]}

Ren, Jie ^{[3
]}

Zeng, Tianlong ^{[1
,2
]}

Xu, Xiufang ^{[3
]}

Li, Jing ^{[1
,2
,4
]}

Liu, Lingyan ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China

[2] Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

[3] Nankai Univ, Coll Chem, Tianjin 300071, Peoples R China

[4] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 23期

基金：

中国国家自然科学基金;

关键词：

MULTIPLY SUBSTITUTED INDOLINES; HIGHLY EFFICIENT; TANDEM SYNTHESIS; CYCLIZATION;

D O I：

10.1021/acs.joc.1c01913

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a protocol for PtI2-catalyzed formal three-component cascade cycloaddition reactions between gamma-aminoalkynes and electron-deficient alkynes to afford highly substituted cyclohexadiene-b-pyrrolidines in good yields. On the basis of the results of the control experiments and density functional theory calculations, we present a plausible mechanism that proceeds via two key intermediates. The overall transformation involves the cleavage and formation of multiple C-C and C-N bonds and a previously unreported reaction mode of a seven-membered nitrogen heterocyclic intermediate.

引用

页码：16614 / 16624

页数：11

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