Facile Synthesis of 4H-1,2,4-Benzothiadiazine-1,1-dioxides

被引：16

作者：

Cherepakha, Artem ^{[1
]}

Kovtunenko, Vladimir O. ^{[1
]}

Tolmachev, Andrey ^{[1
,2
]}

Lukin, Oleg ^{[1
,2
]}

Nazarenko, Konstantin G. ^{[3
]}

机构：

[1] Natl Taras Shevchenko Univ, ChemBio Ctr, UA-01033 Kiev, Ukraine

[2] Enamine Ltd, Kiev, Ukraine

[3] Natl Acad Sci Ukraine, Inst Organ Chem, Kiev, Ukraine

来源：

SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 13期

关键词：

Acylation; amidines; 1; 2; 4-benzothiadiazine-1; 1-dioxide; copper-catalyzed cyclization; sulfonyl chlorides; 1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE; DERIVATIVES; ACID; ANTAGONIST; DIMERS;

D O I：

10.1080/00397911.2010.494815

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[image omitted] o-Bromoarylsulfonylated amidines prepared either by acylation of amidine with o-bromoarylsulfonyl chloride or through the reaction of o-bromoarylsulfoamide with lactime ether underwent Cu(I)-catalyzed intramolecular cyclization to give 4H-1,2,4-benzothiadiazine-1,1-dioxides in good yield. By varying substituents on arylsulfonyl moieties, amidines, and lactime ethers, a small library of structurally diverse 4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives was prepared.

引用

页码：1977 / 1989

页数：13

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