Exosomes in Alzheimer's Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics

被引：54

作者：

Soliman, Hagar M. ^{[1
]}

Ghonaim, Ghada A. ^{[1
]}

Gharib, Shaza M. ^{[1
]}

Chopra, Hitesh ^{[2
]}

Farag, Aya K. ^{[1
]}

Hassanin, Mohamed H. ^{[1
]}

Nagah, Abdalrazeq ^{[1
]}

Emad-Eldin, Mahmoud ^{[3
]}

Hashem, Nevertary E. ^{[1
]}

Yahya, Galal ^{[4
]}

Emam, Sherif E. ^{[1
]}

Hassan, Abdalla E. A. ^{[5
]}

Attia, Mohamed S. ^{[1
]}

机构：

[1] Zagazig Univ, Fac Pharm, Dept Pharmaceut, Zagazig 44519, Egypt

[2] Chitkara Univ, Chitkara Coll Pharm, Chandigarh 140401, Punjab, India

[3] Zagazig Univ, Fac Pharm, Dept Clin, Zagazig 44519, Egypt

[4] Zagazig Univ, Fac Pharm, Dept Microbiol & Immunol, Zagazig 44519, Egypt

[5] Appl Nucle Acids Res Ctr & Chem, Fac Sci, Zagazig 44519, Egypt

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 19期

关键词：

exosomes; neurodegenerative disorders; drug delivery; diagnosis; treatment; cargo; microfluidics; BLOOD-BRAIN-BARRIER; MESENCHYMAL STROMAL CELLS; AMYLOID PRECURSOR PROTEIN; NF-KAPPA-B; CEREBROSPINAL-FLUID; EXTRACELLULAR VESICLES; PROGNOSTIC BIOMARKER; COGNITIVE DECLINE; LUNG-CANCER; TAU-PROTEIN;

D O I：

10.3390/ijms221910794

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exosomes (EXOs) were given attention as an extracellular vesicle (EV) with a pivotal pathophysiological role in the development of certain neurodegenerative disorders (NDD), such as Parkinson's and Alzheimer's disease (AD). EXOs have shown the potential to carry pathological and therapeutic cargo; thus, researchers have harnessed EXOs in drug delivery applications. EXOs have shown low immunogenicity as natural drug delivery vehicles, thus ensuring efficient drug delivery without causing significant adverse reactions. Recently, EXOs provided potential drug delivery opportunities in AD and promising future clinical applications with the diagnosis of NDD and were studied for their usefulness in disease detection and prediction prior to the emergence of symptoms. In the future, the microfluidics technique will play an essential role in isolating and detecting EXOs to diagnose AD before the development of advanced symptoms. This review is not reiterative literature but will discuss why EXOs have strong potential in treating AD and how they can be used as a tool to predict and diagnose this disorder.

引用

页数：20

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