Natural regulatory T cells in autoimmunity

被引：98
|
作者：
Lourenco, Elaine V. [1 ]
La Cava, Antonio [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA
来源：
AUTOIMMUNITY | 2011年 / 44卷 / 01期
基金：
美国国家卫生研究院; 新加坡国家研究基金会;
关键词：
Tregs; CD4(+)CD25(+)FOXP3(+) T cells; natural Tregs; autoimmunity; GROWTH-FACTOR-BETA; SYSTEMIC-LUPUS-ERYTHEMATOSUS; IMMUNOLOGICAL SELF-TOLERANCE; DENDRITIC CELLS; TGF-BETA; CUTTING EDGE; SUPPRESSOR FUNCTION; HELPER TYPE-1; FUNCTIONAL-CHARACTERIZATION; INTERLEUKIN-10; PRODUCTION;
D O I：
10.3109/08916931003782155
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The suppressive/immunomodulatory function of CD4(+)CD25(+)FOXP3(+) regulatory T (Treg) cells is crucial for the maintenance of immune homeostasis, which helps to prevent autoimmunity and reduce the inflammation induced by pathogens and environmental insults. This review summarizes the current knowledge on the types and mechanisms of action of Treg cells and their role in the immune tolerance to self-antigens, with a particular focus on naturally occurring Treg cells.
引用
收藏
页码：33 / 42
页数：10
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