Risk-based breast cancer screening strategies in women

被引:63
作者
Harkness, Elaine F. [1 ,2 ]
Astley, Susan M. [1 ,2 ,3 ]
Evans, D. Gareth [2 ,3 ,4 ,5 ]
机构
[1] Univ Manchester, Fac Biol Med & Hlth, Sch Hlth Sci, Div Informat Imaging & Data Sci, Manchester, Lancs, England
[2] Manchester Univ NHS Fdn Trust, Wythenshawe Hosp, Prevent Breast Canc Ctr, Manchester M23 9LT, Lancs, England
[3] Christie NHS Fdn Trust, Manchester Breast Ctr, Wilmslow Rd, Manchester M20 4BX, Lancs, England
[4] Manchester Univ NHS Fdn Trust, Manchester Ctr Genom Med, NW Genom Lab Hub, Manchester M13 9WL, Lancs, England
[5] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Evolut & Genom Sci,Sch Biol Sci, Manchester, Lancs, England
基金
美国国家卫生研究院;
关键词
Breast cancer screening; Risk stratification; Risk prediction models; Mammographic density; GENETIC SUSCEPTIBILITY; BOADICEA MODEL; UK NHS; MAMMOGRAPHY; PREDICTION; DENSITY; VALIDATION; PREVENTION; ACCURACY; SURVIVAL;
D O I
10.1016/j.bpobgyn.2019.11.005
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The incidence of breast cancer continues to increase worldwide. Population-based screening is available in many countries but may not be the most efficient use of resources, thus interest in risk-based/stratified screening has grown significantly in recent years. An important part of risk-based screening is the incorporation of mammographic density (MD) and single nucleotide polymorphisms (SNPs) into risk prediction models to be combined with classical risk factors. In this article, we discuss different measures of MD and risk prediction models that are available. Risk-stratified screening options including supplemental or alternative screening modalities including digital breast tomosynthesis (DBT), automated ultrasound (ABUS) and magnetic resonance imaging (MRI) are discussed, as well as potential risk-based interventions (diet and lifestyle, chemoprevention and risk-reducing surgery). Furthermore, we look at risk feedback in practice and the cost-effectiveness and acceptability of risk-based screening, highlighting some of the current challenges. (C) 2019 Published by Elsevier Ltd.
引用
收藏
页码:3 / 17
页数:15
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