Baicalein is a novel TLR4-targeting therapeutics agent that inhibits TLR4/HIF-1α/VEGF signaling pathway in colorectal cancer

被引：48

作者：

Chen, Minting ^{[1
]}

Zhong, Keying ^{[2
]}

Tan, Jincheng ^{[2
]}

Meng, Mingjing ^{[2
]}

Liu, Chok Mei ^{[1
]}

Chen, Baisen ^{[1
]}

Huang, Chunhua ^{[1
]}

Wong, Hoi Leong Xavier ^{[1
]}

Bian, Zhaoxiang ^{[1
]}

Su, Tao ^{[2
]}

Kwan, Hiu Yee ^{[1
]}

机构：

[1] Hong Kong Baptist Univ, Sch Chinese Med, Ctr Canc & Inflammat Res, Hong Kong, Peoples R China

[2] Guangzhou Univ Chinese Med, Int Inst Translat Chinese Med, Guangzhou 510006, Guangdong, Peoples R China

来源：

CLINICAL AND TRANSLATIONAL MEDICINE | 2021年 / 11卷 / 11期

关键词：

D O I：

10.1002/ctm2.564

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页数：6

共 10 条

[1] Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications [J].

Cao, Dan ;

Hou, Mei ;

Guan, Yong-song ;

Jiang, Ming ;

Yang, Yu ;

Gou, Hong-feng .

BMC CANCER, 2009, 9

[2] Synchronous and metachronous liver metastases in patients with colorectal cancer-towards a clinically relevant definition [J].

Engstrand, Jennie ;

Stromberg, Cecilia ;

Nilsson, Henrik ;

Freedman, Jacob ;

Jonas, Eduard .

WORLD JOURNAL OF SURGICAL ONCOLOGY, 2019, 17 (01)

[3] Clinicopathological Significances of Tumor-Stroma Ratio (TSR) in Colorectal Cancers: Prognostic Implication of TSR Compared to Hypoxia-Inducible Factor-1α Expression and Microvessel Density [J].

Kang, Guhyun ;

Pyo, Jung-Soo ;

Kim, Nae-Yu ;

Kang, Dong-Wook .

CURRENT ONCOLOGY, 2021, 28 (02) :1314-1324

[4] Targeted Chinese Medicine Delivery by A New Family of Biodegradable Pseudo-Protein Nanoparticles for Treating Triple-Negative Breast Cancer: In Vitro and In Vivo Study [J].

Kwan, Hiu Yee ;

Xu, Qinghua ;

Gong, Ruihong ;

Bian, Zhaoxiang ;

Chu, Chih-Chang .

FRONTIERS IN ONCOLOGY, 2021, 10

[5] Toll-like Receptor 4 (TLR4) Modulation by Synthetic and Natural Compounds: An Update [J].

Peri, Francesco ;

Calabrese, Valentina .

JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (09) :3612-3622

[6] Aptamers: Cutting edge of cancer therapies [J].

Shigdar, Sarah ;

Schrand, Brett ;

Giangrande, Paloma H. ;

de Franciscis, Vittorio .

MOLECULAR THERAPY, 2021, 29 (08) :2396-2411

[7] Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model [J].

Takashima, K. ;

Matsunaga, N. ;

Yoshimatsu, M. ;

Hazeki, K. ;

Kaisho, T. ;

Uekata, M. ;

Hazeki, O. ;

Akira, S. ;

Iizawa, Y. ;

Ii, M. .

BRITISH JOURNAL OF PHARMACOLOGY, 2009, 157 (07) :1250-1262

[8] ESMO consensus guidelines for the management of patients with metastatic colorectal cancer [J].

Van Cutsem, E. ;

Cervantes, A. ;

Adam, R. ;

Sobrero, A. ;

Van Krieken, J. H. ;

Aderka, D. ;

Aranda Aguilar, E. ;

Bardelli, A. ;

Benson, A. ;

Bodoky, G. ;

Ciardiello, F. ;

D'Hoore, A. ;

Diaz-Rubio, E. ;

Douillard, J. -Y. ;

Ducreux, M. ;

Falcone, A. ;

Grothey, A. ;

Gruenberger, T. ;

Haustermans, K. ;

Heinemann, V. ;

Hoff, P. ;

Koehne, C. -H. ;

Labianca, R. ;

Laurent-Puig, P. ;

Ma, B. ;

Maughan, T. ;

Muro, K. ;

Normanno, N. ;

Osterlund, P. ;

Oyen, W. J. G. ;

Papamichael, D. ;

Pentheroudakis, G. ;

Pfeiffer, P. ;

Price, T. J. ;

Punt, C. ;

Ricke, J. ;

Roth, A. ;

Salazar, R. ;

Scheithauer, W. ;

Schmoll, H. J. ;

Tabernero, J. ;

Taieb, J. ;

Tejpar, S. ;

Wasan, H. ;

Yoshino, T. ;

Zaanan, A. ;

Arnold, D. .

ANNALS OF ONCOLOGY, 2016, 27 (08) :1386-1422

[9] Multiple roles of toll-like receptor 4 in colorectal cancer [J].

Yesudhas, Dhanusha ;

Gosu, Vijayakumar ;

Anwar, Muhammad Ayaz ;

Choi, Sangdun .

FRONTIERS IN IMMUNOLOGY, 2014, 5

[10] NMR Studies of Hexaacylated Endotoxin Bound to Wild-type and F126A Mutant MD-2 and MD-2.TLR4 Ectodomain Complexes [J].

Yu, Liping ;

Phillips, Rachel L. ;

Zhang, DeSheng ;

Teghanemt, Athmane ;

Weiss, Jerrold P. ;

Gioannini, Theresa L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (20) :16346-16355

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