The complex epidemiology of extended-spectrum β-lactamase-producing Enterobacteriaceae

被引：19
作者：
Jasper, Ruthy Tal [1 ]
Coyle, Joseph R. [2 ]
Katz, David E. [3 ]
Marchaim, Dror [1 ,4 ]
机构：
[1] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
[2] Michigan Dept Community Hlth, Div Communicable Dis, Bur Dis Control Prevent & Epidemiol, Lansing, MI 48909 USA
[3] Shaare Zedek Med Ctr, Dept Internal Med D, Jerusalem, Israel
[4] Assaf Harofeh Med Ctr, Div Infect Dis, IL-70300 Zerifin, Israel
来源：
FUTURE MICROBIOLOGY | 2015年 / 10卷 / 05期
关键词：
antibiotic stewardship; carbapenem; community acquired; E; coli; Gram negative; healthcare associated; Klebsiella pneumoniae; MDROs; Proteus mirabilis; ST-131; BLOOD-STREAM INFECTIONS; URINARY-TRACT-INFECTIONS; CARBAPENEM-RESISTANT ENTEROBACTERIACEAE; IN-VITRO ACTIVITY; KLEBSIELLA-PNEUMONIAE BACTEREMIA; ESCHERICHIA-COLI INFECTION; CALGARY HEALTH REGION; ST131 CLONAL GROUP; RISK-FACTORS; CTX-M;
D O I：
10.2217/FMB.15.16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Antimicrobial resistance is a growing worldwide iatrogenic complication of modern medical care. Extended-spectrum beta-lactamases have emerged as one of the most successful resistance mechanisms, limiting our therapeutic options to treat various human infections. The dissemination of these enzymes to the community probably signifies an irreversible step. This paper will review the evolution of human infections associated with extended-spectrum beta-lactamase-producing organisms in the past 20 years, and will present and discuss the current challenges, controversies, debates and knowledge gaps in this research field.
引用
收藏
页码：819 / 839
页数：21
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