Adverse effects of immunosuppression after liver transplantation

被引：30

作者：

Noble, Johan ^{[1
]}

Terrec, Florian ^{[1
]}

Malvezzi, Paolo ^{[1
]}

Rostaing, Lionel ^{[1
,2
]}

机构：

[1] Grenoble Univ Hosp, Nephrol Hemodialysis Apheresis & Kidney Transplan, Grenoble, France

[2] Grenoble Alpes Univ, Grenoble, France

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2021年 / 54-55卷

关键词：

Tacrolimus; Liver transplantation; Posttransplant diabetes mellitus; Hypertension; Nephrotoxicity; ONSET DIABETES-MELLITUS; CALCINEURIN INHIBITOR; AMERICAN-SOCIETY; RISK-FACTORS; KIDNEY-TRANSPLANTATION; MYCOPHENOLATE-MOFETIL; METABOLIC SYNDROME; RANDOMIZED-TRIAL; CYCLOSPORINE-A; TACROLIMUS;

D O I：

10.1016/j.bpg.2021.101762

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

After solid organ transplantation the cornerstone of immunosuppression is based on calcineurin inhibitors (CNIs), mostly tacrolimus. However, CNIs have a very narrow therapeutic window. The most important and serious side-effects of CNIs are nephrotoxicity, high blood pressure, post-transplant diabetes mellitus (PTMD), i. e., new-onset diabetes after transplantation (NODAT), dyslipidemia, and modification to the cardiovascular-risk profile. In this review, we will focus on tacrolimus-related toxicities in the setting of liver transplantation.

引用

页数：5

共 58 条

[1] Sirolimus Conversion Regimen Versus Continued Calcineurin Inhibitors in Liver Allograft Recipients: A Randomized Trial [J].

Abdelmalek, M. F. ;

Humar, A. ;

Stickel, F. ;

Andreone, P. ;

Pascher, A. ;

Barroso, E. ;

Neff, G. W. ;

Ranjan, D. ;

Toselli, L. T. ;

Gane, E. J. ;

Scarola, J. ;

Alberts, R. G. ;

Maller, E. S. ;

Lo, C. -M. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2012, 12 (03) :694-705

[2] Cumulative risk of cardiovascular events after orthotopic liver transplantation [J].

Albeldawi, Mazen ;

Aggarwal, Ashish ;

Madhwal, Surabhi ;

Cywinski, Jacek ;

Lopez, Rocio ;

Eghtesad, Bijan ;

Zein, Nizar N. .

LIVER TRANSPLANTATION, 2012, 18 (03) :370-375

[3] Chronic kidney disease and associated mortality after liver transplantation - A time-dependent analysis using measured glomerular filtration rate [J].

Allen, Alina M. ;

Kim, W. Ray ;

Therneau, Terry M. ;

Larson, Joseph J. ;

Heimbach, Julie K. ;

Rule, Andrew D. .

JOURNAL OF HEPATOLOGY, 2014, 61 (02) :286-292

[4] Cyclosporine A, but Not Tacrolimus, Shows Relevant Inhibition of Organic Anion-Transporting Protein 1B1-Mediated Transport of Atorvastatin [J].

Amundsen, Rune ;

Christensen, Hege ;

Zabihyan, Behnaz ;

Asberg, Anders .

DRUG METABOLISM AND DISPOSITION, 2010, 38 (09) :1499-1504

[5] New Onset Diabetes and Non-Alcoholic Fatty Liver Disease after Liver Transplantation [J].

Andrade, Antonio R. ;

Bittencourt, Paulo L. ;

Codes, Liana ;

Evangelista, Maria A. ;

Castro, Alessandra O. ;

Sorte, Ney Boa ;

Almeida, Carolina G. ;

Bastos, Jorge A. ;

Cotrim, Helma P. .

ANNALS OF HEPATOLOGY, 2017, 16 (06) :932-940

[6] The Impact of Preexisting and Post-transplant Diabetes Mellitus on Outcomes Following Liver Transplantation [J].

Aravinthan, Aloysious D. ;

Fateen, Waleed ;

Doyle, Adam C. ;

Venkatachalapathy, Suresh V. ;

Lssachar, Assaf ;

Galvin, Zita ;

Sapisochin, Gonzalo ;

Cattral, Mark S. ;

Ghanekar, Anand ;

McGilvray, Ian D. ;

Selzner, Markus ;

Grant, David R. ;

Selzner, Nazia ;

Lilly, Leslie B. ;

Renner, Eberhard L. ;

Bhat, Mamatha .

TRANSPLANTATION, 2019, 103 (12) :2523-2530

[7] New-Onset Diabetes and Preexisting Diabetes Are Associated With Comparable Reduction in Long-Term Survival After Liver Transplant: A Machine Learning Approach [J].

Bhat, Venkat ;

Tazari, Mahmood ;

Watt, Kymberly D. ;

Bhat, Mamatha .

MAYO CLINIC PROCEEDINGS, 2018, 93 (12) :1794-1802

[8] Factors influencing renal function after liver transplantation. Results from the MOST, an international observational study [J].

Burra, P. ;

Senzolo, M. ;

Masier, A. ;

Prestele, H. ;

Jones, R. ;

Samuel, D. ;

Villamil, F. .

DIGESTIVE AND LIVER DISEASE, 2009, 41 (05) :350-356

[9] Late hypertension after liver transplantation: A comparison of cyclosporine and tacrolimus (FK 506) [J].

Canzanello, VJ ;

Textor, SC ;

Taler, SJ ;

Schwartz, LL ;

Porayko, MK ;

Wiesner, RH ;

Krom, RAF .

LIVER TRANSPLANTATION AND SURGERY, 1998, 4 (04) :328-334

[10] International Liver Transplantation Society Consensus Statement on Immunosuppression in Liver Transplant Recipients [J].

Charlton, Michael ;

Levitsky, Josh ;

Aqel, Bashar ;

O'Grady, John ;

Hemibach, Julie ;

Rinella, Mary ;

Fung, John ;

Ghabril, Marwan ;

Thomason, Ray ;

Burra, Patrizia ;

Little, Ester Coelho ;

Berenguer, Marina ;

Shaked, Abraham ;

Trotter, James ;

Roberts, John ;

Rodriguez-Davalos, Manuel ;

Rela, Mohamed ;

Pomfret, Elizabeth ;

Heyrend, Caroline ;

Gallegos-Orozco, Juan ;

Saliba, Faouzi .

TRANSPLANTATION, 2018, 102 (05) :727-743

← 1 2 3 4 5 6 →