Treatment duration for central line-associated infection caused by Enterococcus spp.: a retrospective evaluation of a multicenter cohort

Objective of this study was to assess the appropriate treatment duration for enterococcal central line-associated bloodstream infections (CLABSIs). This observational, retrospective, multicenter study conducted between 2011 and 2019 enrolled all hospitalized patients with monomicrobial enterococcal CLABSI. Those with infective endocarditis and non-survivors at least 7 days from index blood culture (BC) were excluded. Primary endpoint was 30-day mortality. We enrolled 113 patients, of whom 59% were male, median age was 64 (SD +/- 15) and median Charlson's index score 5 (IQR 3-8). Enterococcus faecalls and Enterococcus faecium were found in 51% and 44% of cases, respectively. Median treatment duration was 11 days (IQR 6-17), and 32% of patients (n=36) received <= 7 days. Characteristics of patients receiving more or less than 7 days of treatment were similar. Central line was removed in 82% (n=93) of cases within a median of 3 days (1-8). At both uni- and multivariate analysis, duration of antibiotic treatment> 7 days was not associated with 30-day mortality [HR 0.41 (95% CI, 0.13-1.24), p= 0.12] even after adjustment with propensity score [HR 0.47 (95% CI 0.17-1.26), p = 0.13]. A 7-day treatment course appears to be safe in non-complicated enterococcal CLABSIs.