γ' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis

被引:6
作者
Pronto-Laborinho, Ana Catarina [1 ]
Lopes, Catarina S. [1 ]
Conceicao, Vasco A. [1 ]
Gromicho, Marta [1 ]
Santos, Nuno C. [1 ]
de Carvalho, Mamede [1 ,2 ]
Carvalho, Filomena A. [1 ]
机构
[1] Univ Lisbon, Inst Med Mol, Fac Med, Lisbon, Portugal
[2] Ctr Hosp Univ Lisboa Norte CHULN, Hosp Santa Maria, Dept Neurosci & Mental Hlth, Lisbon, Portugal
来源
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷
关键词
amyotrophic lateral sclerosis; prognosis; respiratory function; survival; gamma' fibrinogen; DIAGNOSIS; CRITERIA; DISEASE;
D O I
10.3389/fcvm.2021.715842
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder related to neuroinflammation that is associated with increased risk of thrombosis. We aimed to evaluate gamma' fibrinogen plasma level (an in vivo variant of fibrinogen) as a biomarker in ALS, and to test its role as a predictor of disease progression and survival. Sixty-seven consecutive patients with ALS were followed and the results were compared with those from 82 healthy blood donors. Patients were clinically evaluated at the time of blood sampling and on follow-up (every 3 months for the beginning of the follow-up until death) by applying the revised ALS Functional Rating Scale. Human plasma gamma' fibrinogen concentration was quantified using a specific two-site sandwich kit enzyme-linked immunosorbent assay. We found, for the first time, a positive association between gamma' fibrinogen concentration and survival in ALS patients: patients with higher gamma' fibrinogen plasma levels survived longer, and this finding was not influenced by confounders such as age, gender, respiratory impairment, or functionality (ALSFRS-R score). Since increased levels have a positive impact on outcome, this novel biomarker should be further investigated in ALS.
引用
收藏
页数:7
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