Self-assembly behavior of polypeptide graft copolymer

被引：0
|
作者：
Chen, T [1 ]
Tang, DM [1 ]
Lin, JP [1 ]
Zhu, GQ [1 ]
Zhang, SN [1 ]
Tian, XH [1 ]
机构：
[1] E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2005年 / 26卷 / 05期
关键词：
polypeptide; graft copolymer; self-assembly; micelle; fluorescence;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Polymeric micelles of poly (gamma-benzyl L-glutamate) (PBLG)-poly(ethylene oxide) (PEO) graft copolymer were prepared by the dialysis method in deionized water. Fluorescence spectroscopy nuclear magnetic resonance(NMR) and transmission electron microscope(TEM) were used for the investigation of the self-assembly of PBLG-PEO graft copolymer. Fluorescence spectrosco0y measurements suggest that PBLG-PEO graft copolymer associates to form polymeric micelles in water. H-1 NMR measurements further prove that in aqueous medium PBLG-PEO graft copolymer could assemble into polymeric micelles with PBLG segments as the hydrophobic inner core and PEO segments as the hydrophilic shell. The results of the TEM observations show that the polymeric micelles of PBLG-PEO graft copolymer are almost spindly shaped, which are different from the morphology of the spherical micelles formed by PBLG-PEO block copolymer. Polymeric micelles formed by polypeptide copolymer have potential application as drug carrier in controlled-release delivery system.
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页码：988 / 990
页数：3
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