The Hippo Signaling Pathway in Development and Cancer

被引：2002

作者：

Pan, Duojia ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

来源：

DEVELOPMENTAL CELL | 2010年 / 19卷 / 04期

基金：

美国国家卫生研究院;

关键词：

YES-ASSOCIATED PROTEIN; TUMOR-SUPPRESSOR PATHWAY; ORGAN SIZE CONTROL; REGULATE CELL-PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; POLARITY DETERMINANT CRUMBS; MESSENGER-RNA EXPRESSION; SCF-BETA-TRCP; TRANSCRIPTION FACTOR; DOMAIN PROTEIN;

D O I：

10.1016/j.devcel.2010.09.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating the molecular mechanism and physiological function of Hippo signaling in Drosophila and mammals. These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology.

引用

收藏

页码：491 / 505

页数：15

相关论文

共 174 条

[51] The MST1 and hMOB1 Tumor Suppressors Control Human Centrosome Duplication by Regulating NDR Kinase Phosphorylation [J].

Hergovich, Alexander ;

Kohler, Reto S. ;

Schmitz, Debora ;

Vichalkovski, Anton ;

Cornils, Hauke ;

Hemmings, Brian A. .

CURRENT BIOLOGY, 2009, 19 (20) :1692-1702

[52] Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila [J].

Ho, Li-Lun ;

Wei, Xiaomu ;

Shimizu, Takeshi ;

Lai, Zhi-Chun .

DEVELOPMENTAL BIOLOGY, 2010, 337 (02) :274-283

[53] TAZ, a transcriptional modulator of mesenchymal stem cell differentiation [J].

Hong, JH ;

Hwang, ES ;

McManus, MT ;

Amsterdam, A ;

Tian, Y ;

Kalmukova, R ;

Mueller, E ;

Benjamin, T ;

Spiegelman, BM ;

Sharp, PA ;

Hopkins, N ;

Yaffe, MB .

SCIENCE, 2005, 309 (5737) :1074-1078

[54] Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts [J].

Hong, Y ;

Stronach, B ;

Perrimon, N ;

Jan, LY ;

Jan, YN .

NATURE, 2001, 414 (6864) :634-638

[55] Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1 [J].

Hossain, Zakir ;

Ali, Safiah Mohamed ;

Ko, Hui Ling ;

Xu, Jianliang ;

Ng, Chee Peng ;

Guo, Ke ;

Qi, Zeng ;

Ponniah, Sathivel ;

Hong, Wanjin ;

Hunziker, Walter .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (05) :1631-1636

[56] The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP [J].

Huang, JB ;

Wu, S ;

Barrera, J ;

Matthews, K ;

Pan, DJ .

CELL, 2005, 122 (03) :421-434

[57] Hippo Pathway-Dependent and -Independent Roles of RASSF6 [J].

Ikeda, Mitsunobu ;

Kawata, Akira ;

Nishikawa, Misa ;

Tateishi, Yuko ;

Yamaguchi, Masato ;

Nakagawa, Kentaro ;

Hirabayashi, Susumu ;

Bao, Yijun ;

Hidaka, Shiho ;

Hirata, Yukio ;

Hata, Yutaka .

SCIENCE SIGNALING, 2009, 2 (90) :ra59

[58]

Imoto I, 2001, CANCER RES, V61, P6629

[59] Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains [J].

Ishikawa, Hiroyuki O. ;

Takeuchi, Hideyuki ;

Haltiwanger, Robert S. ;

Irvine, Kenneth D. .

SCIENCE, 2008, 321 (5887) :401-404

[60] Akt phosphorylates Mstl and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation [J].

Jang, Sung-Wuk ;

Yang, Seung-Ju ;

Srinivasan, Shanthi ;

Ye, Keqiang .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (42) :30836-30844

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