The Hippo Signaling Pathway in Development and Cancer

被引：2002
作者：
Pan, Duojia [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept Mol Biol & Genet, Baltimore, MD 21205 USA
来源：
DEVELOPMENTAL CELL | 2010年 / 19卷 / 04期
基金：
美国国家卫生研究院;
关键词：
YES-ASSOCIATED PROTEIN; TUMOR-SUPPRESSOR PATHWAY; ORGAN SIZE CONTROL; REGULATE CELL-PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; POLARITY DETERMINANT CRUMBS; MESSENGER-RNA EXPRESSION; SCF-BETA-TRCP; TRANSCRIPTION FACTOR; DOMAIN PROTEIN;
D O I：
10.1016/j.devcel.2010.09.011
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating the molecular mechanism and physiological function of Hippo signaling in Drosophila and mammals. These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology.
引用
收藏
页码：491 / 505
页数：15
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