Genetic Influences on Peripheral Arterial Disease in a Twin Population

被引:29
作者
Wahlgren, Carl Magnus [1 ]
Magnusson, Patrik K. E. [2 ]
机构
[1] Karolinska Univ Hosp, Dept Vasc Surg, S-17176 Stockholm, Sweden
[2] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
关键词
epidemiology; peripheral arterial disease; environmental factors; heritability; twins; ANKLE-BRACHIAL INDEX; SUSCEPTIBILITY; HERITABILITY; GENOME;
D O I
10.1161/ATVBAHA.110.210385
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective-To analyze the contribution of genetic and environmental factors to the development of peripheral arterial disease (PAD) in a large population-based sample of twins. Methods and Results-The understanding of genetics in PAD is still limited. From the Swedish Twin Registry and the national patient discharge registry, 1464 twins with PAD were identified, including 33 monozygotic (MZ) and 42 dizygotic (DZ) concordant pairs and 298 MZ and 1008 DZ discordant pairs. Traditional cardiovascular risk factors were significantly more prevalent in twins with PAD than in those without PAD. Concordances and correlations were higher in MZ compared with DZ twins, indicating genetic influences in PAD. The risk of PAD for persons whose twin had PAD compared with persons whose twin did not have PAD, estimated as an odds ratio, was 17.7 (95% CI, 11.7 to 26.6) for MZ twins and 5.7 (95% CI, 4.1 to 7.9) for DZ twins. In the structural equation models, Mx analyses, genetic effects accounted for 58% (95% CI, 50% to 64%) and nonshared environmental effects for 42% (95% CI, 36% to 50%) of the phenotypic variance among twins. Conclusion-Heritability is an important component, along with unique environmental factors, for the development of PAD. The proportion of the overall PAD heritability attributed to the heritability of cardiovascular risk factors needs to be resolved. Traditional risk factors could explain a major proportion of PAD heritability. A better understanding of the genetics in PAD could identify individuals at increased risk who may benefit from targeted therapies. (Arterioscler Thromb Vasc Biol. 2011;31:678-682.)
引用
收藏
页码:678 / 682
页数:5
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