Pyruvate alleviates high glucose-induced endoplasmic reticulum stress and apoptosis in HK-2 cells

被引：16
|
作者：
Zhang, Xiao Meng [1 ]
Wang, Yi Zhen [2 ]
Tong, Jin Dong [3 ]
Ning, Xu Chao [2 ]
Zhou, Fang Qiang [4 ,5 ]
Yang, Xiu Hong [1 ]
Jin, Hui Min [1 ]
机构：
[1] Fudan Univ, Shanghai Pudong Hosp, Pudong Med Ctr, Dept Nephrol, 2800 Gong Wei Rd, Shanghai, Peoples R China
[2] Qingdao Univ, Dept Clin Med, Affiliated Hosp, Qingdao, Shandong, Peoples R China
[3] Fudan Univ, Shanghai Pudong Hosp, Pudong Med Ctr, Div Vasc Surg, Shanghai, Peoples R China
[4] Shanghai Sandai Pharmaceut R&D Co Ltd, Pudong, Peoples R China
[5] US Off, 200 W Sahara Ave,Unit 604, Las Vegas, NV 89102 USA
来源：
FEBS OPEN BIO | 2020年 / 10卷 / 05期
关键词：
apoptosis; diabetes; diabetic nephropathy; endoplasmic reticulum stress; HK-2; cells; pyruvate; UNFOLDED-PROTEIN-RESPONSE; LACTIC-ACIDOSIS; LENS; PREVENTION; CATARACT; DEATH;
D O I：
10.1002/2211-5463.12834
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endoplasmic reticulum (ER) stress plays a critical role in the development of diabetic nephropathy (DN). We previously demonstrated that pyruvate (Pyr)-enriched oral rehydration solution improved glucometabolic disorders and ameliorated DN outcome in db/db mice. Here, we investigated the effects of Pyr on high glucose-induced ER stress and apoptosis in HK-2 cells. Our results suggest that high glucose can induce reactive oxygen species production, apoptosis and ER stress in HK-2 cells, and that Pyr treatment can ameliorate these effects and restore the expression of key proteins involved in ER stress. Thus, Pyr may have potential for the development of novel strategies for the prevention and treatment of clinical DN.
引用
收藏
页码：827 / 834
页数：8
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