Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists

被引：6

作者：

Laine, Dramane I. ^{[1
]}

Xie, Haibo ^{[1
]}

Buffet, Noemie ^{[1
]}

Foley, James J. ^{[1
]}

Buckley, Peter ^{[1
]}

Webb, Edward F. ^{[1
]}

Widdowson, Katherine L. ^{[1
]}

Palovich, Michael R. ^{[1
]}

Belmonte, Kristen E. ^{[1
]}

机构：

[1] GlaxoSmithkline, King Of Prussia, PA 19406 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 22期

关键词：

muscarinic; antagonists; quaternary; ammonium; salts;

D O I：

10.1016/j.bmcl.2007.09.071

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the course of our research program to develop novel muscarinic receptor antagonists for the treatment of COPD, new tropane carbamate derivatives were identified as potent anti-muscarinic agents. The synthesis, structure-activity relationships and pharmacological evaluation that led to the identification of compound 5o, are described. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6066 / 6069

页数：4

共 16 条

[1] MUSCARINIC RECEPTOR SUBTYPES - IMPLICATIONS FOR LUNG-DISEASE [J].