The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus

被引：5
作者：
Harbuwono, Dante S. [1 ,2 ]
Sazli, Brama I. [1 ,2 ]
Kurniawan, Farid [1 ,2 ]
Darmowidjojo, Budiman [1 ,2 ]
Koesnoe, Sukamto [3 ]
Tahapary, Dicky L. [1 ,2 ]
机构：
[1] Univ Indonesia, Dr Cipto Mangunkusumo Natl Referral Hosp, Div Endocrinol, Fac Med,Dept Internal Med, Jl Diponegoro 71, Cent Jakarta 10430, Indonesia
[2] Univ Indonesia, Fac Med, Indonesian Med Educ & Res Inst, Metab Cardiovasc & Aging Cluster, Jl Diponegoro 71,Cent Jakarta, Jakarta 10430, Indonesia
[3] Univ Indonesia, Fac Med, Dr Cipto Mangunkusumo Natl Referral Hosp, Div Allergy & Immunol,Dept Internal Med, Jl Diponegoro 71,Cent Jakarta, Jakarta 10430, Indonesia
来源：
HELIYON | 2021年 / 7卷 / 05期
关键词：
Ramadan fasting; Diabetes mellitus; Fetuin-A; Insulin resistance; Glycoprotein; FATTY LIVER-DISEASE; GLYCEMIC CONTROL; ENERGY-BALANCE; RISK; PARAMETERS; MANAGEMENT;
D O I：
10.1016/j.heliyon.2021.e06773
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background/Aims: Ramadan fasting creates changes in lifestyle, causing biochemical alterations that affect glucose metabolism and insulin sensitivity. This study aims to assess the impact of Ramadan fasting on glycemic control and Fetuin-A, a glycoprotein that affects insulin resistance, in patients with type 2 diabetes mellitus (T2DM). Materials and methods: This was a prospective study done among 37 patients with T2DM from Internal Medicine Polyclinic in a hospital in Jakarta, Indonesia. Anthropometric data as well as Hemoglobin A1c (HbA1c), Fasting Blood Glucose (FBG), and Fetuin-A levels of the subjects were measured in three time points: before, during, and after Ramadan fasting. A bivariate analysis was done to see the effect of Ramadan fasting on those parameters. Results: Ramadan fasting reduced Fetuin-A levels [median (minimum-maximum), 5.35 (2.91-7.81) vs. 3.22 (2.35-5.60) mg/dl; p = 0.039] four weeks after the end of Ramadan compared to pre-Ramadan. After two weeks of Ramadan fasting, we found a significant reduction in body weight, BMI, FBG, and HbA1c levels which rebounded to baseline level after Ramadan. Conclusion: Ramadan fasting was associated with a significant decrease in Fetuin-A level post Ramadan.
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页数：4
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