Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease?

被引：24

作者：

Ghavami, Shaghayegh Baradaran ^{[1
]}

Aghdaei, Hamid Asadzadeh ^{[1
]}

Sorrentino, Dario ^{[2
,3
]}

Shahrokh, Shabnam ^{[1
]}

Farmani, Maryam ^{[1
]}

Ashrafian, Fatemeh ^{[4
]}

Dore, Maria Pina ^{[5
]}

Raftar, Shahrbanoo Keshavarz Azizi ^{[4
]}

Khoramjoo, Seyed Mobin ^{[1
]}

Zali, Mohammad Reza ^{[6
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Basic & Mol Epidemiol Gastrointestinal Disorders, Res Inst Gastroenterol & Liver Dis, Tehran 1983963113, Iran

[2] Virginia Tech Carilion Sch Med, IBD Ctr, Div Gastroenterol, 3 Riverside Cirde, Roanoke, VA 24016 USA

[3] Univ Udine, Dept Clin & Expt Med Sci, Sch Med, I-33100 Udine, Italy

[4] Pasteur Inst Iran, Microbiol Res Ctr, Tehran 1316943551, Iran

[5] Univ Sassari, Dept Med Surg & Expt Sci, Sch Med, I-07100 Sassari, Italy

[6] Shahid Beheshti Univ Med Sci, Gastroenterol & Liver Dis Res Ctr, Res Inst Gastroenterol & Liver Dis, Tehran 1983963113, Iran

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 15期

关键词：

inflammatory bowel diseases; ulcerative colitis; Crohn's disease; probiotics; dendritic cells; mucosal tolerance; REGULATORY T-CELLS; ULCERATIVE-COLITIS; IN-VITRO; LACTOBACILLUS-ACIDOPHILUS; BIFIDOBACTERIUM-LACTIS; CROHNS-DISEASE; MATURATION; BACTERIA; DCS; ACID;

D O I：

10.3390/ijms22158274

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammatory bowel diseases (IBDs) are immune-mediated, chronic relapsing diseases with a rising prevalence worldwide in both adult and pediatric populations. Treatment options for immune-mediated diseases, including IBDs, are traditional steroids, immunomodulators, and biologics, none of which are capable of inducing long-lasting remission in all patients. Dendritic cells (DCs) play a fundamental role in inducing tolerance and regulating T cells and their tolerogenic functions. Hence, modulation of intestinal mucosal immunity by DCs could provide a novel, additional tool for the treatment of IBD. Recent evidence indicates that probiotic bacteria might impact immunomodulation both in vitro and in vivo by regulating DCs' maturation and producing tolerogenic DCs (tolDCs) which, in turn, might dampen inflammation. In this review, we will discuss this evidence and the mechanisms of action of probiotics and their metabolites in inducing tolDCs in IBDs and some conditions associated with them.

引用

页数：17

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