Helminth-Induced IgE and Protection Against Allergic Disorders

被引：19

作者：

Hamid, Firdaus ^{[1
,2
]}

Amoah, Abena S. ^{[2
,3
]}

van Ree, Ronald ^{[4
,5
]}

Yazdanbakhsh, Maria ^{[2
]}

机构：

[1] Hasanuddin Univ, Fac Med, Dept Microbiol, Makassar, Indonesia

[2] Leiden Univ, Med Ctr, Dept Parasitol, NL-2333 ZA Leiden, Netherlands

[3] Noguchi Mem Inst Med Res, Dept Parasitol, Accra, Ghana

[4] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, NL-1105 AZ Amsterdam, Netherlands

[5] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1105 AZ Amsterdam, Netherlands

来源：

IGE ANTIBODIES: GENERATION AND FUNCTION | 2015年 / 388卷

关键词：

REACTIVE CARBOHYDRATE DETERMINANTS; PLACEBO-CONTROLLED TRIAL; IN-VITRO DIAGNOSIS; CROSS-REACTIVITY; ASCARIS-LUMBRICOIDES; ANTHELMINTIC TREATMENT; IMMUNOGLOBULIN-E; MITE ALLERGENS; BASOPHIL RESPONSIVENESS; GEOHELMINTH PARASITES;

D O I：

10.1007/978-3-319-13725-4_5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune response against helminths and allergens is generally characterized by high levels of IgE and increased numbers of Th2 cells, eosinophils, and mast cells, yet the clinical outcome with respect to immediate hypersensitivity and inflammation is clearly not the same. High levels of IgE are seen to allergens during helminth infections; however, these IgE responses do not translate into allergy symptoms. This chapter summarizes the evidence of the association between helminth infections and allergic disorders. It discusses how helminth infection can lead to IgE cross-reactivity with allergens and how this IgE has poor biological activity. This information is important for developing new diagnostic methods and treatments for allergic disorders in low-to-middle-income countries.

引用

页码：91 / 108

页数：18

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