EYA4 Promotes Cell Proliferation Through Downregulation of p27Kip1 in Glioma

被引：16
|
作者：
Li, Zhaoming [1 ]
Qiu, Ran [2 ]
Qiu, Xia [3 ]
Tian, Tian [4 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Oncol, Zhengzhou, Henan, Peoples R China
[2] Wuhan Inst Bioengn, Wuhan, Hubei, Peoples R China
[3] Shangqiu Med Sch, Dept Med, Shangqiu, Peoples R China
[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Henan, Peoples R China
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2018年 / 49卷 / 05期
关键词：
Eya4; P27Kip1; Glioma; Cell proliferation; Prognosis; CYCLE PROGRESSION; BREAST-CANCER; P27; P27(KIP1); EXPRESSION; MARKER; GROWTH; GENE; INTERACTS; PROTEINS;
D O I：
10.1159/000493631
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Background/Aims: Accumulating evidence suggests that Eyes Absent Homologue 4 (EYA4) plays an important role in tumorigenesis and progression of various cancers. However, the role of EYA4 in glioma development is still unclear. Methods: The expression of EYA4 was examined in glioma tissues by immunohistochemistry. Cell viability and apoptosis were analyzed by CCK-8, BrdU assay, and flow cytometry. Results: We found that EYA4 was upregulated in glioma, and its expression was positively correlated with advanced tumor stage. Moreover, higher expression of EYA4 predicted a worse overall survival in patients with glioma. Forced overexpression of EYA4 enhanced glioma cell proliferation, and EYA4 suppressed the expression of p27Kip1 directly in these cells. Furthermore, Six1 was required for EYA4 to suppress the expression of p27Kip1 in glioma. Conclusion: Together, we demonstrate that EYA4 promotes cell proliferation by directly suppressing the expression of p27Kip1 in glioma. (C) 2018 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码：1856 / 1869
页数：14
相关论文
共 50 条
  • [41] miR-196a-mediated downregulation of p27kip1protein promotes prostate cancer proliferation and relates to biochemical recurrence after radical prostatectomy
    Zhan, Bin
    Huang, Linjin
    Chen, Yachun
    Ye, Wen
    Li, Jingkun
    Chen, Jianhui
    Yang, Sheng
    Jiang, Wei
    PROSTATE, 2020, 80 (12) : 1024 - 1037
  • [42] Loss of Canonical Insulin Signaling Accelerates Vascular Smooth Muscle Cell Proliferation and Migration Through Changes in p27Kip1 Regulation
    Lightell, Daniel James, Jr.
    Moss, Stephanie Collier
    Woods, Thomas Cooper
    ENDOCRINOLOGY, 2011, 152 (02) : 651 - 658
  • [43] Lgr4 Promotes Glioma Cell Proliferation through Activation of Wnt Signaling
    Yu, Chun-Yong
    Liang, Guo-Biao
    Du, Peng
    Liu, Yun-Hui
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2013, 14 (08) : 4907 - 4911
  • [44] LncRNA GAS5 Inhibits Cellular Proliferation by Targeting P27Kip1
    Luo, Gang
    Liu, Dong
    Huang, Chao
    Wang, Miao
    Xiao, Xingyuan
    Zeng, Fuqing
    Wang, Liang
    Jiang, Guosong
    MOLECULAR CANCER RESEARCH, 2017, 15 (07) : 789 - 799
  • [45] Upregulated SKP2 Empowers Epidermal Proliferation Through Downregulation of P27 Kip1
    Tang, Lipeng
    Zhang, Bowen
    Li, Guanzhuo
    Qiu, Xinmin
    Dai, Zixin
    Liu, Hongying
    Zhu, Ying
    Feng, Bing
    Su, Zuqing
    Han, Wenhui
    Huang, Huilin
    Li, Qiuping
    Zhang, Zihao
    Wang, Maojie
    Liu, Huazhen
    Chen, Yuchao
    Zhang, Yanmei
    Wu, Dinghong
    Zheng, Xirun
    Liu, Taohua
    Zhao, Jie
    Li, Chutian
    Zheng, Guangjuan
    ANNALS OF DERMATOLOGY, 2024, 36 (05) : 282 - 291
  • [46] EYA4 promotes breast cancer progression and metastasis through its role in replication stress avoidance
    Avalos, Barbara de la Pena
    Tropee, Romain
    Duijf, Pascal H. G.
    Dray, Eloise
    MOLECULAR CANCER, 2023, 22 (01)
  • [47] Increased Expression of NPM1 Suppresses p27Kip1 Function in Cancer Cells
    Kometani, Tatsuya
    Arai, Takuya
    Chibazakura, Taku
    CANCERS, 2020, 12 (10) : 1 - 14
  • [48] GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis
    Xu, Hui
    Sun, Lili
    Zheng, Yanwen
    Yu, Shuye
    Jia Ou-yang
    Han, Hui
    Dai, Xingliang
    Yu, Xiaoting
    Li, Ming
    Lan, Qing
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 495 (01) : 446 - 453
  • [49] Clinical significance of cyclin-dependent kinase inhibitor p27Kip1 expression and proliferation in non-Hodgkin's lymphoma:: independent prognostic value of p27Kip1
    Moller, MB
    Skjodt, K
    Mortensen, LS
    Pedersen, NT
    BRITISH JOURNAL OF HAEMATOLOGY, 1999, 105 (03) : 730 - 736
  • [50] p27Kip1 - p(RhoB)lematic in lung cancer
    Podmirseg, Silvio R.
    Vosper, Jonathan
    Hengst, Ludger
    JOURNAL OF PATHOLOGY, 2019, 248 (01) : 3 - 5
12345