EYA4 Promotes Cell Proliferation Through Downregulation of p27Kip1 in Glioma

被引：16
|
作者：
Li, Zhaoming [1 ]
Qiu, Ran [2 ]
Qiu, Xia [3 ]
Tian, Tian [4 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Oncol, Zhengzhou, Henan, Peoples R China
[2] Wuhan Inst Bioengn, Wuhan, Hubei, Peoples R China
[3] Shangqiu Med Sch, Dept Med, Shangqiu, Peoples R China
[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Henan, Peoples R China
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2018年 / 49卷 / 05期
关键词：
Eya4; P27Kip1; Glioma; Cell proliferation; Prognosis; CYCLE PROGRESSION; BREAST-CANCER; P27; P27(KIP1); EXPRESSION; MARKER; GROWTH; GENE; INTERACTS; PROTEINS;
D O I：
10.1159/000493631
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Background/Aims: Accumulating evidence suggests that Eyes Absent Homologue 4 (EYA4) plays an important role in tumorigenesis and progression of various cancers. However, the role of EYA4 in glioma development is still unclear. Methods: The expression of EYA4 was examined in glioma tissues by immunohistochemistry. Cell viability and apoptosis were analyzed by CCK-8, BrdU assay, and flow cytometry. Results: We found that EYA4 was upregulated in glioma, and its expression was positively correlated with advanced tumor stage. Moreover, higher expression of EYA4 predicted a worse overall survival in patients with glioma. Forced overexpression of EYA4 enhanced glioma cell proliferation, and EYA4 suppressed the expression of p27Kip1 directly in these cells. Furthermore, Six1 was required for EYA4 to suppress the expression of p27Kip1 in glioma. Conclusion: Together, we demonstrate that EYA4 promotes cell proliferation by directly suppressing the expression of p27Kip1 in glioma. (C) 2018 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码：1856 / 1869
页数：14
相关论文
共 50 条
  • [21] MicroRNA-196a promotes cervical cancer proliferation through the regulation of FOXO1 and p27Kip1
    Hou, T.
    Ou, J.
    Zhao, X.
    Huang, X.
    Huang, Y.
    Zhang, Y.
    BRITISH JOURNAL OF CANCER, 2014, 110 (05) : 1260 - 1268
  • [22] MicroRNA-196a promotes cervical cancer proliferation through the regulation of FOXO1 and p27Kip1
    T Hou
    J Ou
    X Zhao
    X Huang
    Y Huang
    Y Zhang
    British Journal of Cancer, 2014, 110 : 1260 - 1268
  • [23] Downregulation of microRNA-429 inhibits cell proliferation by targeting p27Kip1 in human prostate cancer cells
    Ouyang, Yongri
    Gao, Ping
    Zhu, Baoyi
    Chen, Xi
    Lin, Fang
    Wang, Xi
    Wei, Junxia
    Zhang, Huizhong
    MOLECULAR MEDICINE REPORTS, 2015, 11 (02) : 1435 - 1441
  • [24] P27Kip1:: A key regulator of skeletal muscle satellite cell proliferation
    Spangenburg, EE
    Chakravarthy, MV
    Booth, FW
    CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2002, (403) : S221 - S227
  • [25] A CDK-independent function of p27kip1 controls cell proliferation
    Belletti, Barbara
    Pellizzari, Ilenia
    Fabris, Linda
    Berton, Stefania
    D'Andrea, Sara
    Segatto, Ilenia
    Armenia, Joshua
    Baldassarre, Gustavo
    CANCER RESEARCH, 2012, 72
  • [26] Genetic characterization of p27kip1 and stathmin in controlling cell proliferation in vivo
    Berton, Stefania
    Pellizzari, Ilenia
    Fabris, Linda
    D'Andrea, Sara
    Segatto, Ilenia
    Canzonieri, Vincenzo
    Marconi, Daniela
    Schiappacassi, Monica
    Benevol, Sara
    Gattei, Valter
    Colombatti, Alfonso
    Belletti, Barbara
    Baldassarre, Gustavo
    CELL CYCLE, 2014, 13 (19) : 3100 - 3111
  • [27] miR-222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1
    Sun, Chaoyang
    Li, Na
    Zhou, Bo
    Yang, Zongyuan
    Ding, Dong
    Weng, Danhui
    Meng, Li
    Wang, Shixuan
    Zhou, Jianfeng
    Ma, Ding
    Chen, Gang
    ONCOLOGY LETTERS, 2013, 6 (02) : 507 - 512
  • [28] Genistein inhibits rat aortic smooth muscle cell proliferation through the induction of p27kip1
    Yu, Ji-Yeon
    Lee, Jung-Jin
    Lim, Yong
    Kim, Tack-Joong
    Jin, Yong-Ri
    Sheen, Yhun Y.
    Yun, Yeo-Pyo
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 107 (01) : 90 - 98
  • [29] KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells
    Nakamura, Satoki
    Okinaka, Keiji
    Hirano, Isao
    Ono, Takaaki
    Sugimoto, Yuya
    Shigeno, Kazuyuki
    Fujisawa, Shinya
    Shinjo, Kaori
    Ohnishi, Kazunori
    LEUKEMIA RESEARCH, 2008, 32 (09) : 1358 - 1365
  • [30] MicroRNA miR-24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1 and p16INK4a
    Giglio, Simona
    Cirombella, Roberto
    Amodeo, Rachele
    Portaro, Luciano
    Lavra, Luca
    Vecchione, Andrea
    JOURNAL OF CELLULAR PHYSIOLOGY, 2013, 228 (10) : 2015 - 2023
12345