EYA4 Promotes Cell Proliferation Through Downregulation of p27Kip1 in Glioma

被引：16
|
作者：
Li, Zhaoming [1 ]
Qiu, Ran [2 ]
Qiu, Xia [3 ]
Tian, Tian [4 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Oncol, Zhengzhou, Henan, Peoples R China
[2] Wuhan Inst Bioengn, Wuhan, Hubei, Peoples R China
[3] Shangqiu Med Sch, Dept Med, Shangqiu, Peoples R China
[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Henan, Peoples R China
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2018年 / 49卷 / 05期
关键词：
Eya4; P27Kip1; Glioma; Cell proliferation; Prognosis; CYCLE PROGRESSION; BREAST-CANCER; P27; P27(KIP1); EXPRESSION; MARKER; GROWTH; GENE; INTERACTS; PROTEINS;
D O I：
10.1159/000493631
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Background/Aims: Accumulating evidence suggests that Eyes Absent Homologue 4 (EYA4) plays an important role in tumorigenesis and progression of various cancers. However, the role of EYA4 in glioma development is still unclear. Methods: The expression of EYA4 was examined in glioma tissues by immunohistochemistry. Cell viability and apoptosis were analyzed by CCK-8, BrdU assay, and flow cytometry. Results: We found that EYA4 was upregulated in glioma, and its expression was positively correlated with advanced tumor stage. Moreover, higher expression of EYA4 predicted a worse overall survival in patients with glioma. Forced overexpression of EYA4 enhanced glioma cell proliferation, and EYA4 suppressed the expression of p27Kip1 directly in these cells. Furthermore, Six1 was required for EYA4 to suppress the expression of p27Kip1 in glioma. Conclusion: Together, we demonstrate that EYA4 promotes cell proliferation by directly suppressing the expression of p27Kip1 in glioma. (C) 2018 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码：1856 / 1869
页数：14
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