EYA4 Promotes Cell Proliferation Through Downregulation of p27Kip1 in Glioma

被引：16
|
作者：
Li, Zhaoming [1 ]
Qiu, Ran [2 ]
Qiu, Xia [3 ]
Tian, Tian [4 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Oncol, Zhengzhou, Henan, Peoples R China
[2] Wuhan Inst Bioengn, Wuhan, Hubei, Peoples R China
[3] Shangqiu Med Sch, Dept Med, Shangqiu, Peoples R China
[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Henan, Peoples R China
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2018年 / 49卷 / 05期
关键词：
Eya4; P27Kip1; Glioma; Cell proliferation; Prognosis; CYCLE PROGRESSION; BREAST-CANCER; P27; P27(KIP1); EXPRESSION; MARKER; GROWTH; GENE; INTERACTS; PROTEINS;
D O I：
10.1159/000493631
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Background/Aims: Accumulating evidence suggests that Eyes Absent Homologue 4 (EYA4) plays an important role in tumorigenesis and progression of various cancers. However, the role of EYA4 in glioma development is still unclear. Methods: The expression of EYA4 was examined in glioma tissues by immunohistochemistry. Cell viability and apoptosis were analyzed by CCK-8, BrdU assay, and flow cytometry. Results: We found that EYA4 was upregulated in glioma, and its expression was positively correlated with advanced tumor stage. Moreover, higher expression of EYA4 predicted a worse overall survival in patients with glioma. Forced overexpression of EYA4 enhanced glioma cell proliferation, and EYA4 suppressed the expression of p27Kip1 directly in these cells. Furthermore, Six1 was required for EYA4 to suppress the expression of p27Kip1 in glioma. Conclusion: Together, we demonstrate that EYA4 promotes cell proliferation by directly suppressing the expression of p27Kip1 in glioma. (C) 2018 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码：1856 / 1869
页数：14
相关论文
共 50 条
  • [1] MiR-196a Is Upregulated in Gastric Cancer and Promotes Cell Proliferation by Downregulating p27kip1
    Sun, Ming
    Liu, Xiang-hua
    Li, Jin-hai
    Yang, Jin-song
    Zhang, Er-bao
    Yin, Dan-dan
    Liu, Zhi-li
    Zhou, Jing
    Ding, Ying
    Li, Su-qin
    Wang, Zhao-xia
    Cao, Xiu-feng
    De, Wei
    MOLECULAR CANCER THERAPEUTICS, 2012, 11 (04) : 842 - 852
  • [2] PKC alpha affects cell cycle progression and proliferation in human RPE cells through the downregulation of p27kip1
    Gao, Qianying
    Tan, Juan
    Ma, Ping
    Ge, Jian
    Liu, Yaqin
    Sun, Xuerong
    Zhou, Lian
    MOLECULAR VISION, 2009, 15 (283-88): : 2683 - 2695
  • [3] miRNA-24-3p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting p27Kip1
    Lu, Kangping
    Wang, Jingxuan
    Song, Ying
    Zhao, Shu
    Liu, Hang
    Tang, Dabei
    Pan, Bo
    Zhao, Hong
    Zhang, Qingyuan
    ONCOLOGY REPORTS, 2015, 34 (02) : 995 - 1002
  • [4] YAP promotes the proliferation of neuroblastoma cells through decreasing the nuclear location of p27Kip1 mediated by Akt
    Shen, Xiya
    Xu, Xingxing
    Xie, Changnan
    Liu, Huitao
    Yang, Danlu
    Zhang, Jingjing
    Wu, Qian
    Feng, Wenjin
    Wang, Ling
    Du, Leilei
    Xuan, Lina
    Meng, Chaobo
    Zhang, Haitao
    Wang, Wei
    Wang, Ying
    Xie, Tian
    Huang, Zhihui
    CELL PROLIFERATION, 2020, 53 (02)
  • [5] MicroRNA-196a promotes cervical cancer proliferation through the regulation of FOXO1 and p27Kip1
    Hou, T.
    Ou, J.
    Zhao, X.
    Huang, X.
    Huang, Y.
    Zhang, Y.
    BRITISH JOURNAL OF CANCER, 2014, 110 (05) : 1260 - 1268
  • [6] Genetic characterization of p27kip1 and stathmin in controlling cell proliferation in vivo
    Berton, Stefania
    Pellizzari, Ilenia
    Fabris, Linda
    D'Andrea, Sara
    Segatto, Ilenia
    Canzonieri, Vincenzo
    Marconi, Daniela
    Schiappacassi, Monica
    Benevol, Sara
    Gattei, Valter
    Colombatti, Alfonso
    Belletti, Barbara
    Baldassarre, Gustavo
    CELL CYCLE, 2014, 13 (19) : 3100 - 3111
  • [7] miR-222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1
    Sun, Chaoyang
    Li, Na
    Zhou, Bo
    Yang, Zongyuan
    Ding, Dong
    Weng, Danhui
    Meng, Li
    Wang, Shixuan
    Zhou, Jianfeng
    Ma, Ding
    Chen, Gang
    ONCOLOGY LETTERS, 2013, 6 (02) : 507 - 512
  • [8] LIM domain only 2 induces glioma invasion via cytosolic p27KIP1
    Park, Cheol Gyu
    Sohn, Young-Woo
    Kim, Eun-Jung
    Kim, Sung-Hak
    Kim, Sung-Chan
    Kim, Hyunggee
    TUMOR BIOLOGY, 2016, 37 (02) : 2473 - 2480
  • [9] Expression of Pirh2, a p27Kip1 ubiquitin ligase, in hepatocellular carcinoma: correlation with p27Kip1 and cell proliferation
    Huang, Xiaodong
    Qian, Xiaoli
    Cheng, Chun
    He, Song
    Sun, Linlin
    Ke, Qing
    Zhang, Li
    Pan, Xia
    He, Fei
    Wang, Qiuhong
    Meng, Jie
    Ni, Runzhou
    Shen, Aiguo
    HUMAN PATHOLOGY, 2011, 42 (04) : 507 - 515
  • [10] Cell proliferation and p27Kip1 expression in endophytic schneiderian papillomas
    Schwerer, MJ
    Sailer, A
    Kraft, K
    Maier, H
    LARYNGOSCOPE, 2002, 112 (05) : 852 - 857
12345