Bioactive Compounds from Marine Sponges and Algae: Effects on Cancer Cell Metabolome and Chemical Structures

被引:12
作者
Esposito, Roberta [1 ,2 ]
Federico, Serena [1 ]
Glaviano, Francesca [2 ,3 ]
Somma, Emanuele [3 ,4 ]
Zupo, Valerio [3 ]
Costantini, Maria [1 ]
机构
[1] Stn Zool Anton Dohrn, Dept Ecosustainable Marine Biotechnol, Via Ammiraglio Ferdinando Acton, I-80133 Naples, Italy
[2] Univ Naples Federico II, Complesso Univ Monte St Angelo, Dept Biol, Via Cinthia 21, I-80126 Naples, Italy
[3] Ischia Marine Ctr, Dept Ecosustainable Marine Biotechnol, Stn Zool Anton Dohrn, I-80077 Ischia, Italy
[4] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy
关键词
algae; cancer; sponges; marine eukaryotes; metabolism; MASS-SPECTROMETRY DATA; MAGNETIC-RESONANCE-SPECTROSCOPY; PEAK ALIGNMENT; IN-VITRO; LIQUID-CHROMATOGRAPHY; ANALYTICAL PLATFORMS; CYTOTOXIC ACTIVITY; IDENTIFICATION; MICROALGAE; URINE;
D O I
10.3390/ijms231810680
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metabolomics represent the set of small organic molecules generally called metabolites, which are located within cells, tissues or organisms. This new "omic" technology, together with other similar technologies (genomics, transcriptomics and proteomics) is becoming a widely used tool in cancer research, aiming at the understanding of global biology systems in their physiologic or altered conditions. Cancer is among the most alarming human diseases and it causes a considerable number of deaths each year. Cancer research is one of the most important fields in life sciences. In fact, several scientific advances have been made in recent years, aiming to illuminate the metabolism of cancer cells, which is different from that of healthy cells, as suggested by Otto Warburg in the 1950s. Studies on sponges and algae revealed that these organisms are the main sources of the marine bioactive compounds involved in drug discovery for cancer treatment and prevention. In this review, we analyzed these two promising groups of marine organisms to focus on new metabolomics approaches for the study of metabolic changes in cancer cell lines treated with chemical extracts from sponges and algae, and for the classification of the chemical structures of bioactive compounds that may potentially prove useful for specific biotechnological applications.
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页数:20
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